Phenotypes associated with this allele

• Allele Symbol: Rhot1^tm1.1Jmsu
• Allele Name: targeted mutation 1.1, Janet M Shaw
• Allele ID: MGI:5619347
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mnx1^tm4(cre)Tmj/Mnx1^+ Rhot1^tm1.1Jmsu/Rhot1^tm1.2Jmsu	involves: 129 * 129S1/Sv * C57BL/6 * SJL	MGI:5619357
cn2	Rhot1^tm1.1Jmsu/Rhot1^tm1.1Jmsu Tg(Eno2-cre)39Jme/0	involves: 129 * C57BL/6 * C57BL/6J * SJL	MGI:5619354

Genotype
MGI:5619357

cn1

• Allelic Composition: Mnx1^tm4(cre)Tmj/Mnx1⁺; Rhot1^tm1.1Jmsu/Rhot1^tm1.2Jmsu
• Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:216408 )

• mice do not exhibit any obvious phenotypes

Genotype
MGI:5619354

cn2

• Allelic Composition: Rhot1^tm1.1Jmsu/Rhot1^tm1.1Jmsu; Tg(Eno2-cre)39Jme/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * SJL

mortality/aging

premature death ( J:216408 )

• premature death by around P35

growth/size/body

slow postnatal weight gain ( J:216408 )

• mice fail to gain weight with age

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:216408 )

• mice develop severe movement defects with age

limb grasping ( J:216408 )

• mice exhibit hindlimb clasping by P14

abnormal tail movements ( J:216408 )

• mice develop a stiff tail

spasticity ( J:216408 )

• mice develop hind-limb spasticity

nervous system

abnormal brainstem morphology ( J:216408 )

• brainstem and lumbar spinal regions contain aggregate bodies that are not seen in controls, resembling Bunina bodies which are eosinophilic inclusions

• Bunina-like structures appear to be extracellular

skeleton

kyphosis ( J:216408 )

• mice develop kyphosis with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
motor neuron disease		DOID:231		J:216408