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Allele Symbol Allele Name Allele ID |
Hprt1tm1(CAG-Gys1*)Jjg targeted mutation 1, Joan J Guinovart MGI:5618914 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• extensive brain accumulation of glycogen
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• extensive brain accumulation of glycogen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in spite of increased skeletal muscle glycogen level, mice reach exhaustion earlier than wild-type controls in a treadmill endurance test
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• mice cover a shorter distance than wild-type controls in a treadmill endurance test
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• under resting conditions, adult mice show a 7-fold increase in skeletal muscle glycogen level relative to wild-type controls
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• at the point of exhaustion following treadmill exercise, mice show a greater reduction of glycogen content in skeletal muscle than wild-type controls
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• under resting conditions, adult mice show a 7-fold increase in skeletal muscle glycogen level relative to wild-type controls
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• in spite of increased skeletal muscle glycogen level, mice reach exhaustion earlier than wild-type controls in a treadmill endurance test
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• mice cover a shorter distance than wild-type controls in a treadmill endurance test
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• adult soleus muscle exhibits lower oxygen consumption affecting all mitochondrial states relative to wild-type muscle
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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