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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Acacatm1Dejs
targeted mutation 1, David E James
MGI:5618483
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Acacatm1Dejs/Acacatm1Dejs
Tg(Cd4-cre)1Cwi/? 		involves: C57BL/6 * DBA/2 MGI:5702405
cn2
 		Acacatm1Dejs/Acacatm1Dejs
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)1100Mjb/? 		involves: C57BL/6 * DBA/2 MGI:5702406


Genotype
MGI:5702405
cn1
Allelic
Composition		 Acacatm1Dejs/Acacatm1Dejs
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acacatm1Dejs mutation (0 available); any Acaca mutation (124 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid metabolism ( J:209886 )
• synthesis of C16:0 and C18:1 fatty acids by Listeria infected T cells is reduced relative to controls
• total quantities of C16:0, C18:0, and C18:1 are not significantly changed 24 hours after activation with Listeria

immune system
immune system phenotype ( J:209886 )
N
• thymocyte T cell profiles are normal
• peripheral B cell numbers are normal
decreased T cell number ( J:209886 )
• CD8+ T cells in spleen and peripheral lymph nodes are dramatically reduced
• significant reductions in CD4+ T cells are also observed
decreased memory T cell number ( J:209886 )
• reduced activated memory T cell numbers
abnormal T cell physiology ( J:209886 )
• reduced survival of peripheral CD8+ T cells
• supplementation of cultured cells with exogenous fatty acids improves survival

hematopoietic system
decreased T cell number ( J:209886 )
• CD8+ T cells in spleen and peripheral lymph nodes are dramatically reduced
• significant reductions in CD4+ T cells are also observed
decreased memory T cell number ( J:209886 )
• reduced activated memory T cell numbers
abnormal T cell physiology ( J:209886 )
• reduced survival of peripheral CD8+ T cells
• supplementation of cultured cells with exogenous fatty acids improves survival




Genotype
MGI:5702406
cn2
Allelic
Composition		 Acacatm1Dejs/Acacatm1Dejs
Tg(Cd4-cre)1Cwi/?
Tg(TcraTcrb)1100Mjb/?
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acacatm1Dejs mutation (0 available); any Acaca mutation (124 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:209886 )
• significant CD8+ T cell expansion after Listeria-OVA exposure
• cell survival is reduced

hematopoietic system
increased T cell proliferation ( J:209886 )
• significant CD8+ T cell expansion after Listeria-OVA exposure
• cell survival is reduced

cellular
increased T cell proliferation ( J:209886 )
• significant CD8+ T cell expansion after Listeria-OVA exposure
• cell survival is reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory