Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nsun4tm1.2Arte mutation
(0 available);
any
Nsun4 mutation
(34 available)
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embryo
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• severely retarded growth with no clearly discernible anatomical structures at age E8.5
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growth/size/body
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• severely retarded growth with no clearly discernible anatomical structures at age E8.5
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mortality/aging
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• no mice born
• severely retarded growth with no clearly discernible anatomical structures at age E8.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nsun4tm1.2Arte mutation
(0 available);
any
Nsun4 mutation
(34 available)
Tg(Ckmm-cre)5Khn mutation
(4 available)
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cardiovascular system
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• heart-to-body weight ratio increases with age
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cellular
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• increased mitochondrial mass as indicated by increased mtDNA level in heart at age 20 weeks
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• strong increase in mitochondrial de novo transcription and steady-state transcript levels in heart
• strong inhibition of translation and severely reduced levels of assembled ribosomes in heart
• severely reduced ribosome self-assembly in heart
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• drastically reduced steady-state levels of assembled OXPHOS complexes containing mtDNA-encoded polypeptides in heart mitochondria from age 20 weeks
• unchanged steady-state levels of assembled OXPHOS complexes containing mtDNA-encoded polypeptides in heart mitochondria at age 5 weeks
• steady-state levels of complex II
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mortality/aging
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• mice die before age 25 weeks
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growth/size/body
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• heart-to-body weight ratio increases with age
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Analysis Tools