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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nsun4tm1.2Arte
targeted mutation 1.2, TaconicArtemis
MGI:5618266
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nsun4tm1.2Arte/Nsun4tm1.2Arte involves: C57BL/6 * FVB/N * SJL MGI:6294481
cn2
 		Nsun4tm1.2Arte/Nsun4tm1.2Arte
Tg(Ckmm-cre)5Khn/0 		involves: C57BL/6 * FVB/N * SJL MGI:6294482


Genotype
MGI:6294481
hm1
Allelic
Composition		 Nsun4tm1.2Arte/Nsun4tm1.2Arte
Genetic
Background		 involves: C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nsun4tm1.2Arte mutation (0 available); any Nsun4 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryonic growth retardation ( J:211012 )
• severely retarded growth with no clearly discernible anatomical structures at age E8.5

growth/size/body
embryonic growth retardation ( J:211012 )
• severely retarded growth with no clearly discernible anatomical structures at age E8.5

mortality/aging
embryonic lethality, complete penetrance ( J:211012 )
• no mice born
• severely retarded growth with no clearly discernible anatomical structures at age E8.5




Genotype
MGI:6294482
cn2
Allelic
Composition		 Nsun4tm1.2Arte/Nsun4tm1.2Arte
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nsun4tm1.2Arte mutation (0 available); any Nsun4 mutation (37 available)
Tg(Ckmm-cre)5Khn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased heart weight ( J:211012 )
• heart-to-body weight ratio increases with age

cellular
increased mitochondrial DNA content ( J:211012 )
• increased mitochondrial mass as indicated by increased mtDNA level in heart at age 20 weeks
abnormal mitochondrial physiology ( J:211012 )
• strong increase in mitochondrial de novo transcription and steady-state transcript levels in heart
• strong inhibition of translation and severely reduced levels of assembled ribosomes in heart
• severely reduced ribosome self-assembly in heart
abnormal oxidative phosphorylation ( J:211012 )
• drastically reduced steady-state levels of assembled OXPHOS complexes containing mtDNA-encoded polypeptides in heart mitochondria from age 20 weeks
• unchanged steady-state levels of assembled OXPHOS complexes containing mtDNA-encoded polypeptides in heart mitochondria at age 5 weeks
• steady-state levels of complex II

mortality/aging
premature death ( J:211012 )
• mice die before age 25 weeks

growth/size/body
increased heart weight ( J:211012 )
• heart-to-body weight ratio increases with age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory