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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eomestm1.1Twa
targeted mutation 1.1, Thierry Walzer
MGI:5617491
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Eomestm1.1Twa/?
Tbx21tm1Glm/Tbx21tm1Glm 		involves: 129S6/SvEvTac * C57BL/6N MGI:5699431
cx2
 		Eomestm1.1Twa/?
Tg(Itgax-TGFBR2)1Flv/? 		involves: C3H * C57BL/6 * C57BL/6N MGI:5699436
cx3
 		Eomestm1.1Twa/?
Il15tm1Imx/Il15tm1Imx 		involves: C57BL/6 * C57BL/6N MGI:5699434
cx4
 		Eomestm1.1Twa/?
Tg(CD2-Tbx21)#Staka/? 		involves: C57BL/6N MGI:5699438


Genotype
MGI:5699431
cx1
Allelic
Composition		 Eomestm1.1Twa/?
Tbx21tm1Glm/Tbx21tm1Glm
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Twa mutation (1 available); any Eomes mutation (41 available)
Tbx21tm1Glm mutation (2 available); any Tbx21 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell differentiation ( J:210160 )
• Eomes- NK cells are lacking

hematopoietic system
abnormal NK cell differentiation ( J:210160 )
• Eomes- NK cells are lacking




Genotype
MGI:5699436
cx2
Allelic
Composition		 Eomestm1.1Twa/?
Tg(Itgax-TGFBR2)1Flv/?
Genetic
Background		 involves: C3H * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Twa mutation (1 available); any Eomes mutation (41 available)
Tg(Itgax-TGFBR2)1Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell differentiation ( J:210160 )
• no effect on Eomes- NK cells
• Eomes+ NK cell number is increased

hematopoietic system
abnormal NK cell differentiation ( J:210160 )
• no effect on Eomes- NK cells
• Eomes+ NK cell number is increased




Genotype
MGI:5699434
cx3
Allelic
Composition		 Eomestm1.1Twa/?
Il15tm1Imx/Il15tm1Imx
Genetic
Background		 involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Twa mutation (1 available); any Eomes mutation (41 available)
Il15tm1Imx mutation (5 available); any Il15 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell differentiation ( J:210160 )
• Eomes- NK cells are lacking
• Eomes+ NK cells are lacking

hematopoietic system
abnormal NK cell differentiation ( J:210160 )
• Eomes- NK cells are lacking
• Eomes+ NK cells are lacking




Genotype
MGI:5699438
cx4
Allelic
Composition		 Eomestm1.1Twa/?
Tg(CD2-Tbx21)#Staka/?
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomestm1.1Twa mutation (1 available); any Eomes mutation (41 available)
Tg(CD2-Tbx21)#Staka mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell differentiation ( J:210160 )
• large populations of Eomes- NK cells
• decrease in all populations of Eomes+ NK cells

hematopoietic system
abnormal NK cell differentiation ( J:210160 )
• large populations of Eomes- NK cells
• decrease in all populations of Eomes+ NK cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory