Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1Rgsc422 mutation
(0 available);
any
Ifih1 mutation
(43 available)
|
|
|
mortality/aging
|
• rarely survive to 4 weeks of age
|
|
• rarely survive to 4 weeks of age
|
growth/size/body
immune system
|
• develop severe multi-organ autoimmune disease
• inflammation is more severe than in heterozygous mice
|
renal/urinary system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1Rgsc422 mutation
(0 available);
any
Ifih1 mutation
(43 available)
|
|
|
mortality/aging
|
• 60% of mice die within 24 weeks of birth
|
growth/size/body
immune system
|
• increase in the numbers of conventional DCs and plasmacytoid DCs in the spleen
|
|
• upregulation of an activation marker, CD69, in CD4+ and CD8+ T cells
|
|
• upregulation of the cell surface marker CD86 on macrophages in the spleen suggesting that these cells are activated
|
|
• increased production of inflammatory cytokines in the kidney
|
|
• increased production of inflammatory chemokines in the kidney
|
|
• upregulation of the cell surface marker CD86 on conventional DCs and plasmacytoid DCs in the spleen suggesting that these cells are activated
|
|
• develop severe multi-organ autoimmune disease
|
|
• liver calcification is seen, indicative of chronic inflammation
|
|
• lupus-like nephritis develops 6-8 weeks after birth
• transfer of bone marrow cells to irradiated wild-type mice induces a milder nephritis
|
|
• mild infiltration of polymorphonuclear leukocytes in the haired skin of the forehead
|
liver/biliary system
|
• liver calcification is seen, indicative of chronic inflammation
|
integument
|
• mild infiltration of polymorphonuclear leukocytes in the haired skin of the forehead
|
renal/urinary system
|
• lupus-like nephritis develops 6-8 weeks after birth
• transfer of bone marrow cells to irradiated wild-type mice induces a milder nephritis
|
hematopoietic system
|
• increase in the numbers of conventional DCs and plasmacytoid DCs in the spleen
|
|
• upregulation of an activation marker, CD69, in CD4+ and CD8+ T cells
|
|
• upregulation of the cell surface marker CD86 on macrophages in the spleen suggesting that these cells are activated
|
homeostasis/metabolism
Allelic Composition |
Ifih1Rgsc422/Ifih1+ Ifnar1tm1Agt/Ifnar1+
|
|
Genetic Background |
involves: 129S2/SvPas * C57BL/6JJcl * DBA/2JJcl |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1Rgsc422 mutation
(0 available);
any
Ifih1 mutation
(43 available)
Ifnar1tm1Agt mutation
(11 available);
any
Ifnar1 mutation
(59 available)
|
|
|
immune system
|
• less severe than in mice wild-type for Ifnar1
|
renal/urinary system
|
• less severe than in mice wild-type for Ifnar1
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1Rgsc422 mutation
(0 available);
any
Ifih1 mutation
(43 available)
Mavstm1Aki mutation
(0 available);
any
Mavs mutation
(36 available)
|
|
|
immune system
N |
• mice do not develop glomerulonephritis, enhanced expression of cytokines and chemokines or increased numbers of immune cells in the spleen, unlike mice wild-type for Mavs
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifih1Rgsc422 mutation
(0 available);
any
Ifih1 mutation
(43 available)
Mavstm1Aki mutation
(0 available);
any
Mavs mutation
(36 available)
|
|
|
immune system
|
• less severe than in mice wild-type for Mavs
|
renal/urinary system
|
• less severe than in mice wild-type for Mavs
|