Phenotypes associated with this allele

• Allele Symbol: Lep^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5616351
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lep^tm1b(EUCOMM)Hmgu/Lep^tm1b(EUCOMM)Hmgu	C57BL/6N-Lep^tm1b(EUCOMM)Hmgu/Bay	MGI:6288550

Genotype
MGI:6288550

hm1

• Allelic Composition: Lep^{tm1b(EUCOMM)Hmgu}/Lep^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Lep^{tm1b(EUCOMM)Hmgu}/Bay
• Cell Lines: HEPD0764_6_C04

Data Sources

IMPC Data for Lep

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - BCM

increased anxiety-related response ( J:211773 )

IMPC - BCM

decreased grip strength ( J:211773 )

IMPC - BCM

decreased vertical activity ( J:211773 )

IMPC - BCM

decreased locomotor activity ( J:211773 )

IMPC - BCM

cardiovascular system

decreased heart weight ( J:211773 )

IMPC - BCM

increased cardiac stroke volume ( J:211773 )

IMPC - BCM

decreased heart rate ( J:211773 )

IMPC - BCM

prolonged QRS complex duration ( J:211773 )

♂

IMPC - BCM

hematopoietic system

decreased spleen weight ( J:211773 )

♀

IMPC - BCM

immune system

decreased spleen weight ( J:211773 )

♀

IMPC - BCM

integument

abnormal coat appearance ( J:211773 )

♀

IMPC - BCM

limbs/digits/tail

short tibia ( J:211773 )

IMPC - BCM

reproductive system

female infertility ( J:211773 )

♀

IMPC - BCM

male infertility ( J:211773 )

♂

IMPC - BCM

skeleton

short tibia ( J:211773 )

IMPC - BCM

vision/eye

increased cornea thickness ( J:211773 )

♂

IMPC - BCM

abnormal eye posterior chamber depth ( J:211773 )

IMPC - BCM

abnormal retina inner nuclear layer morphology ( J:211773 )

IMPC - BCM

decreased total retina thickness ( J:211773 )

IMPC - BCM