All Phenotypes Ephb4<b2b2412Clo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ephb4^b2b2412Clo
Bench to Bassinet Program (B2B/CVDC), mutation 2412 Cecilia Lo
MGI:5614904

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ephb4^b2b2412Clo/Ephb4^b2b2412Clo	C57BL/6J-Ephb4^b2b2412Clo	MGI:5614941

Allelic Composition	Ephb4^b2b2412Clo/Ephb4^b2b2412Clo
Genetic Background	C57BL/6J-Ephb4^b2b2412Clo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb4^b2b2412Clo mutation (0 available); any Ephb4 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Mutant 2412-003-2 (E15.5) presents with parallel outflow tracts suggesting overriding aorta. Also observed is premature constriction of the patent ductus.

cardiovascular system

abnormal pulmonary artery morphology ( J:175213 )

• hypoplastic pulmonary artery (PA)

abnormal aortic arch morphology ( J:175213 )

vascular ring ( J:175213 )

overriding aortic valve ( J:175213 )

perimembraneous ventricular septal defect ( J:175213 )

• perimembranous ventricular septal defect

renal/urinary system

kidney cyst ( J:175213 )

polycystic kidney ( J:175213 )

hydronephrosis ( J:175213 )

growth/size/body

kidney cyst ( J:175213 )

polycystic kidney ( J:175213 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cystic kidney disease		DOID:2975		J:175213

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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