Phenotypes associated with this allele

• Allele Symbol: Atf6^tm1Hota
• Allele Name: targeted mutation 1, Gokhan S Hotamisligil
• Allele ID: MGI:5614122
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atf6^tm1Hota/Atf6^tm1Hota Tg(Ins2-cre)25Mgn/0	B6.Cg-Atf6^tm1Hota Tg(Ins2-cre)25Mgn	MGI:5614219
cn2	Atf6^tm1Hota/Atf6^tm1Hota Tg(Ins2-cre)25Mgn/0 Tg(Ins2-GP)1Kbuw/0	involves: C57BL/6 * DBA	MGI:5614220

Genotype
MGI:5614219

cn1

• Allelic Composition: Atf6^tm1Hota/Atf6^tm1Hota; Tg(Ins2-cre)25Mgn/0
• Genetic Background: B6.Cg-Atf6^tm1Hota Tg(Ins2-cre)25Mgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased insulin sensitivity ( J:213542 )

• slightly with lower insulin secretion curve in a glucose stimulated insulin secretion assay

decreased physiological sensitivity to xenobiotic ( J:213542 )

• increased cell death in primary islets that is not decreased in the presence of TUDCA

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:213542 )

N • beta cells develop normally

increased pancreatic islet cell apoptosis ( J:213542 )

• increased cell death in primary islets that is not decreased in the presence of TUDCA

growth/size/body

growth/size/body region phenotype ( J:213542 )

N • mice exhibit normal body weight

cellular

increased pancreatic islet cell apoptosis ( J:213542 )

• increased cell death in primary islets that is not decreased in the presence of TUDCA

Genotype
MGI:5614220

cn2

• Allelic Composition: Atf6^tm1Hota/Atf6^tm1Hota; Tg(Ins2-cre)25Mgn/0; Tg(Ins2-GP)1Kbuw/0
• Genetic Background: involves: C57BL/6 * DBA

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:213542 )

• TUDCA-treated mice fail to exhibit a protective effect from diabetes with decreased insulin content and number of apoptotic cells in islets compared wild-type mice