Atf6^tm1Hota
Targeted Allele Detail

Summary

• Symbol: Atf6^tm1Hota
• Name: activating transcription factor 6; targeted mutation 1, Gokhan S Hotamisligil
• MGI ID: MGI:5614122
• Synonyms: ATF6 fl, Atf6^tm1.1Hota
• Gene: Atf6 Location: Chr1:170532243-170695340 bp, - strand Genetic Position: Chr1, 76.96 cM
• Alliance: Atf6^tm1Hota page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213542
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 8 and 9 were floxed. (J:213542)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atf6 Mutation: 45 strains or lines available

References

• Original: J:213542 Engin F, et al., Restoration of the unfolded protein response in pancreatic beta cells protects mice against type 1 diabetes. Sci Transl Med. 2013 Nov 13;5(211):211ra156
• All: 16 reference(s)