All Phenotypes Rr29<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rr29⁺
wild type
MGI:5613144

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rr29^Hx/Rr29⁺	B10.D2-H2^d/nSnJ-Rr29^Hx	MGI:3711142
ht2	Rr29^Hx/Rr29⁺	B10.D2/nSn-Rr29^Hx/J	MGI:3051422
ht3	Rr29^Hx/Rr29⁺	C3Fe.Cg-Rr29^Hx	MGI:3711058
ht4	Rr29^Dz/Rr29⁺	C57BL/6J-Rr29^Dz	MGI:3851925
ht5	Rr29^Dz/Rr29⁺	(C57BL/6J-Rr29^Dz x CAST/Ei)F1	MGI:3851926
ht6	Rr29^Hxl3/Rr29⁺	C57BL/6J-Rr29^Hxl3	MGI:3051418
ht7	Rr29^rgsc1116/Rr29⁺	D2;B6-Rr29^rgsc1116/Rbrc	MGI:3714743
ht8	Rr29^Hx/Rr29⁺	involves: C57BL/10SnJ * DBA/2J	MGI:5634906
cx9	Hm/Hm⁺ Rr29^Hx/Rr29⁺	C3Fe.Cg-Hm +/+ Rr29^Hx	MGI:3711061
cx10	Rr29^tm1.1Bobh/Rr29⁺ Shh^tm1Chg/Shh⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:5613161

Allelic Composition	Rr29^Hx/Rr29⁺
Genetic Background	B10.D2-H2^d/nSnJ-Rr29^Hx

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29^Hx mutation (1 available); any Rr29 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:13476 )

• both forefeet have preaxial polydactyly

• the polydactyly in the hind feet arises as a duplication of the terminal phalanx of either the first or fifth toe

short radius ( J:13476 )

• in the forelimbs, one or both or neither radius are foreshortened

short tibia ( J:13476 )

• tibias are either absent or greatly reduced in size

skeleton

short radius ( J:13476 )

• in the forelimbs, one or both or neither radius are foreshortened

short tibia ( J:13476 )

• tibias are either absent or greatly reduced in size

Allelic Composition	Rr29^Hx/Rr29⁺
Genetic Background	B10.D2/nSn-Rr29^Hx/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29^Hx mutation (1 available); any Rr29 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal zone of polarizing activity morphology ( J:27442 )

• zone of polarizing activity is duplicated at anterior margin of fore- and hindlimb buds

polydactyly ( J:87798 , J:27442 )

• preaxial polydactyly (J:87798)

• supernumerary metacarpals, metatarsals, and digits (J:87798)

• hindlimbs usually more affected than forelimbs (J:87798)

• a III-II-II-III-IV-V digit pattern (J:27442)

abnormal tarsal bone morphology ( J:27442 )

• mirror-image duplication of the second and third tarsal bones

abnormal talus morphology ( J:87798 )

• short talus

short radius ( J:87798 )

short tibia ( J:87798 )

hemimelia ( J:87798 )

• hemimelia caused by shortening of the radius, tibia, and talus

skeleton

abnormal tarsal bone morphology ( J:27442 )

• mirror-image duplication of the second and third tarsal bones

abnormal talus morphology ( J:87798 )

• short talus

short radius ( J:87798 )

short tibia ( J:87798 )

homeostasis/metabolism

increased bleeding time ( J:31800 )

• bleeding time is increased 2.6- to 3-fold compared to controls

• platelet numbers and function appear normal

embryo

abnormal zone of polarizing activity morphology ( J:27442 )

• zone of polarizing activity is duplicated at anterior margin of fore- and hindlimb buds

Allelic Composition	Rr29^Hx/Rr29⁺
Genetic Background	C3Fe.Cg-Rr29^Hx

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29^Hx mutation (1 available); any Rr29 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Macroscopic pictures of ventral hind limbs and skeletal hind limbs of Rr29^Hx/Shh⁺ , Rr29^Hx/Rr29^Hx, Hm/⁺, Hm/Hm, and Hm/⁺ Rr29^Hx/Shh⁺ mice

limbs/digits/tail

polydactyly ( J:68687 )

• preaxial polydactyly and normal tibia

Allelic Composition	Rr29^Dz/Rr29⁺
Genetic Background	C57BL/6J-Rr29^Dz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29^Dz mutation (0 available); any Rr29 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:150728 )

• preaxial polydactyly is seen on the hindlimbs

• Background Sensitivity: limb phenotype is seen in mice on a C57BL/6J background but not in mice crossed to CAST/Ei, no indication of the direction of the cross was provided

Allelic Composition	Rr29^Dz/Rr29⁺
Genetic Background	(C57BL/6J-Rr29^Dz x CAST/Ei)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29^Dz mutation (0 available); any Rr29 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:150728 )

N	• Background Sensitivity: unlike mice on a C57BL/6J background no limb phenotype is seen in mice crossed to CAST/Ei, no indication of the direction of the cross was provided

Allelic Composition	Rr29^Hxl3/Rr29⁺
Genetic Background	C57BL/6J-Rr29^Hxl3

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29^Hxl3 mutation (1 available); any Rr29 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Skeletal phenotypes of Rr29^Hx/Rr29^Hx and Rr29^Hxl3/Shh⁺ mice

limbs/digits/tail

polydactyly ( J:87798 )

• preaxial polydactyly

• supernumerary metacarpals, metatarsals, and digits

• hemimelia caused by shortening of the radius, tibia, and talus

• hindlimbs usually more affected than forelimbs

Allelic Composition	Rr29^rgsc1116/Rr29⁺
Genetic Background	D2;B6-Rr29^rgsc1116/Rbrc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29^rgsc1116 mutation (1 available); any Rr29 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polydactyly ( J:121866 )

• 80% preaxial polydactyly at G³

Allelic Composition	Rr29^Hx/Rr29⁺
Genetic Background	involves: C57BL/10SnJ * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29^Hx mutation (1 available); any Rr29 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:31035 )

• noticeable by E11-E12

• Background Sensitivity: variable penetrance

ectrodactyly ( J:31035 )

• occurred in the forepaws

polydactyly ( J:31035 )

• occurred in the hindpaws only

abnormal metatarsal bone morphology ( J:31035 )

decreased metatarsal bone number ( J:31035 )

hemimelia ( J:31035 )

• tibial and radial

skeleton

abnormal metatarsal bone morphology ( J:31035 )

decreased metatarsal bone number ( J:31035 )

mortality/aging

neonatal lethality, incomplete penetrance ( J:31035 )

• mice dying during the neonatal period had cleft palate

craniofacial

cleft hard palate ( J:31035 )

• cause of death of some newborns

digestive/alimentary system

cleft hard palate ( J:31035 )

• cause of death of some newborns

growth/size/body

cleft hard palate ( J:31035 )

• cause of death of some newborns

Allelic Composition	Hm/Hm⁺ Rr29^Hx/Rr29⁺
Genetic Background	C3Fe.Cg-Hm +/+ Rr29^Hx

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hm mutation (3 available); any Hm mutation (3 available)
Rr29^Hx mutation (1 available); any Rr29 mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Macroscopic pictures of ventral hind limbs and skeletal hind limbs of Rr29^Hx/Shh⁺ , Rr29^Hx/Rr29^Hx, Hm/⁺, Hm/Hm, and Hm/⁺ Rr29^Hx/Shh⁺ mice

limbs/digits/tail

polydactyly ( J:68687 )

• preaxial polydactyly with normal tibia

syndactyly ( J:68687 )

• syndactyly is more severe than seen in single heterozygous Hm mutants

interdigital webbing ( J:68687 )

• complete webbing of all hind feet digits that extend to the tip of the distal phalanges

Allelic Composition	Rr29^tm1.1Bobh/Rr29⁺ Shh^tm1Chg/Shh⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29^tm1.1Bobh mutation (0 available); any Rr29 mutation (2 available)
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:208849 )

• range of limb phenotypes similar to mice homozygous for Rr29^tm1.1Bobh

oligodactyly ( J:208849 )

• 40% of mice have 4 digits, 30% have 4 phalanges and 3 metatarsels, 10% have 3 digits and 20% have 3 sets of phalanges and 2 metatarsels

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