Phenotypes associated with this allele

• Allele Symbol: Ptbp2^tm1.2Dblk
• Allele Name: targeted mutation 2.1, Douglas Black
• Allele ID: MGI:5608588
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptbp2^tm1.2Dblk/Ptbp2^tm1.2Dblk	involves: 129S2/SvPas * FVB/N	MGI:5608592

Genotype
MGI:5608592

hm1

• Allelic Composition: Ptbp2^tm1.2Dblk/Ptbp2^tm1.2Dblk
• Genetic Background: involves: 129S2/SvPas * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:207976 )

• pups die at birth due to respiratory failure

behavior/neurological

paralysis ( J:207976 )

• at birth pups appear paralyzed and do not respond to touch

nervous system

neurodegeneration ( J:207976 )

• neuronal cultures exhibit neurite retraction, membrane blebbing and shrinkage, and nuclear condensation by the second week

• all neurons die in culture by the end of the third week

respiratory system

respiratory failure ( J:207976 )

• at birth pups fail to initiate breathing