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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Semg1tm1Kemi
targeted mutation 1, Kenji Miyado
MGI:5607932
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Semg1tm1Kemi/Semg1tm1Kemi involves: 129 * C57BL/6N MGI:5607934
cx2
 		Semg1tm1Kemi/Semg1tm1Kemi
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: 129 * C57BL/6 * C57BL/6N * DBA/2 MGI:5607935


Genotype
MGI:5607934
hm1
Allelic
Composition		 Semg1tm1Kemi/Semg1tm1Kemi
Genetic
Background		 involves: 129 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Semg1tm1Kemi mutation (1 available); any Semg1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Seminal vesicle appearance and absence of copulatory plugs in Semg1tm1Kemi/Semg1tm1Kemi and Semg1tm2Kemi/Semg1tm2Kemi mice

reproductive system
reproductive system phenotype ( J:207389 )
N
• the seminal vesicle epithelium morphology appears similar to controls
• fertilization in an in vitro fertilization assay rates of fertilized eggs are comparable to controls
reduced male fertility ( J:207389 )
• strongly reduced fertility with homozygous males siring an average litter size of 0.63 +/- 0.13 pups compared to 5.23 +/- 0.53 and 4.96 +/- 0.42 pups for wild-type and heterozygous mice, respectively
abnormal sperm physiology ( J:207389 )
• intrauterine death of sperm

behavior/neurological
failure of copulatory plug deposition ( J:207389 )
• copulatory plugs are not formed in female mice mated with homozygous males
• however, mating behavior is normal, sperm are normally produced and rates of motile and hyperactivated sperm are indistinguishable from controls




Genotype
MGI:5607935
cx2
Allelic
Composition		 Semg1tm1Kemi/Semg1tm1Kemi
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Semg1tm1Kemi mutation (1 available); any Semg1 mutation (30 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Membrane disruption of intrauterine sperm in Semg1tm1Kemi/Semg1tm1Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 or Semg1tm2Kemi/Semg1tm2Kemi Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0

reproductive system
abnormal sperm physiology ( J:207389 )
• intrauterine death of sperm
abnormal sperm motility ( J:207389 )
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla
premature acrosome reaction ( J:207389 )
• ejaculated sperm have already undergone the acrosomal reaction inside the uterus

cellular
abnormal sperm motility ( J:207389 )
• sperm are rarely seen in the isthmus of the oviduct and are unable to move into the ampulla




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory