All Phenotypes Hprt1<tm5(Camk2a-BACE1)Geno> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:215577 )

• females sustain normal body weight until 9 months of age, however they show marked reductions in weight at 12 months of age

behavior/neurological

impaired social transmission of food preference ( J:215577 )

• preference for cued food in 4 month old mice is intact in the short-term memory test but is affected in the long-term memory component

• at 6 months of age, memory for cued food is altered for both short-term memory and long-term memory, with reduced preference in both delays, indicating an age-dependent reduction in semantic-like retrieval

abnormal habituation to a new environment ( J:215577 )

• mice show delayed habituation to a novel environment with increasing age

• mice exhibit increased exploration activity during the initial 3 hours of habituation to a novel environment, first seen as a trend at 3 months and with significant differences at 6 and 12 months of age

abnormal spatial reference memory ( J:215577 )

• in the open-field water maze, mice show increased path length to find the hidden platform at 6 and 12 months of age, indicating decreased spatial precision

• in the open-field water maze, mutants show about 50% reduction in directed swims and a modest decrease of focal searches, are slower to abstain from wall hugging and maintain scanning, and have a high percentage (about 35%) of chaining responses to solve the task

impaired spatial working memory ( J:215577 )

• in the spontaneous alternation task of the Y-maze, 6 month old mice show deficient alternations indicating a spatial working memory deficit

decreased anxiety-related response ( J:215577 )

• In the light/dark box, mice remain longer in the light compartment, indicating decreased anxiety

• in the elevated plus maze, mice show a trend in spending more time in the open arms and an increase in exploration (total distance moved)

abnormal motor coordination/balance ( J:215577 )

• in the open-field water maze, mutants do not show an age-dependent reduction in swim speed as is seen controls, such that at 12 months of age, mutants show enhanced swim speed

short stride length ( J:215577 )

• stride length is reduced in 6 month old females

• however, mice show normal motor coordination and other gait characteristics

decreased locomotor activity ( J:215577 )

• habituated mice show a decrease in locomotor activity at 6 months of age during both light and dark periods

nervous system

abnormal nervous system morphology ( J:215577 )

• toxic APP metabolites are formed that accumulate intra- and extraneuronally in hippocampus and cortex

• accumulation of 56 kDa oligomeric APP (amyloid beta*56) deposits and amyloid beta hexamers in the absence of plaque deposition

astrocytosis ( J:215577 )

• astrogliosis in dentate gyrus, hippocampal area CA1, piriform and parietal cortices at 6 and 12 months of age

neuronal intranuclear inclusions ( J:215577 )

• neuronal nuclear inclusions in hippocampal areas, however amyloid plaques are infrequent

neurodegeneration ( J:215577 )

• degenerated neurons are prominent and frequent

taste/olfaction

taste/olfaction phenotype ( J:215577 )

N	• mice show normal olfactory abilities

Allelic Composition	Hprt1^{tm5(Camk2a-BACE1)Geno}/Y
Genetic Background	B6.129P2-Hprt1^{tm5(Camk2a-BACE1)Geno}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm5(Camk2a-BACE1)Geno} mutation (0 available); any Hprt1 mutation (1274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype