Hprt1tm5(Camk2a-BACE1)Geno
Targeted Allele Detail
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Symbol: |
Hprt1tm5(Camk2a-BACE1)Geno |
Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 5, Genoway |
MGI ID: |
MGI:5607312 |
Synonyms: |
PLB4 |
Gene: |
Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
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Alliance: |
Hprt1tm5(Camk2a-BACE1)Geno page
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Germline Transmission: |
Earliest citation of germline transmission:
J:215577
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Hprt1tm5(Camk2a-BACE1)Geno expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
BACE1 (23621) |
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Mutation details: The construct targeted to the locus the human BACE1 gene under the control of Camk2a promoter. Western blot analysis of brain lysates indicates that BACE1 expression levels are about 1.8-fold and 2.2-fold higher at 6 and 12 months of age, respectively.
(J:215577)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hprt1 Mutation: |
1274 strains or lines available
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Original: |
J:215577 Plucinska K, et al., Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypes. J Neurosci. 2014 Aug 6;34(32):10710-28 |
All: |
4 reference(s) |
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