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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cavin4tm1.2Tue
targeted mutation 1.2, Tomomi Ueyama
MGI:5607305
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cavin4tm1.2Tue/Cavin4tm1.2Tue involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5607309


Genotype
MGI:5607309
hm1
Allelic
Composition		 Cavin4tm1.2Tue/Cavin4tm1.2Tue
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cavin4tm1.2Tue mutation (0 available); any Cavin4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Attenuation of phenylephrine-induced cardiac hypertrophy in Cavin4tm1.2Tue/Cavin4tm1.2Tue mice

cardiovascular system
cardiovascular system phenotype ( J:207401 )
N
• under physiological conditions cardiac mass and function are indistinguishable from wild-type controls
decreased response of heart to induced stress ( J:207401 )
• induction of cardiac hypertrophy by phenylephrine infusion is suppressed

homeostasis/metabolism
decreased response of heart to induced stress ( J:207401 )
• induction of cardiac hypertrophy by phenylephrine infusion is suppressed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory