Cavin4tm1.2Tue
Targeted Allele Detail
|
Symbol: |
Cavin4tm1.2Tue |
Name: |
caveolae associated 4; targeted mutation 1.2, Tomomi Ueyama |
MGI ID: |
MGI:5607305 |
Synonyms: |
MURC- |
Gene: |
Cavin4 Location: Chr4:48663514-48673492 bp, + strand Genetic Position: Chr4, 26.23 cM, cytoband B2
|
Alliance: |
Cavin4tm1.2Tue page
|
|
Attenuation of phenylephrine-induced cardiac hypertrophy in Cavin4tm1.2Tue/Cavin4tm1.2Tue mice
Show the 1 phenotype image(s) involving this allele.
|
|
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A loxP site was inserted in the 5' untranslated region and an FRT flanked neo cassette and loxP site were inserted downstream of exon 1. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exon 1.
(J:207401)
|
|
Generation of the Cavin4tm1.1Tue and Cavin4tm1.2Tue alleles |
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Cavin4 Mutation: |
15 strains or lines available
|
|
Original: |
J:207401 Ogata T, et al., MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3811-6 |
All: |
4 reference(s) |
|