Phenotypes associated with this allele

• Allele Symbol: Ehmt1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5605800
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ehmt1^tm1b(EUCOMM)Hmgu/Ehmt1^tm1b(EUCOMM)Hmgu	C57BL/6N-Ehmt1^tm1b(EUCOMM)Hmgu/Nju	MGI:6262349
hm2	Ehmt1^tm1b(EUCOMM)Hmgu/Ehmt1^tm1b(EUCOMM)Hmgu	C57BL/6N-Ehmt1^tm1b(EUCOMM)Hmgu/Wtsi	MGI:6262350
ht3	Ehmt1^tm1b(EUCOMM)Hmgu/Ehmt1^+	C57BL/6N-Ehmt1^tm1b(EUCOMM)Hmgu/Nju	MGI:5757034
ht4	Ehmt1^tm1b(EUCOMM)Hmgu/Ehmt1^+	C57BL/6N-Ehmt1^tm1b(EUCOMM)Hmgu/Wtsi	MGI:6262348

Genotype
MGI:6262349

hm1

• Allelic Composition: Ehmt1^{tm1b(EUCOMM)Hmgu}/Ehmt1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ehmt1^{tm1b(EUCOMM)Hmgu}/Nju
• Cell Lines: HEPD0734_3_F01

Data Sources

IMPC Data for Ehmt1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - MARC

Genotype
MGI:6262350

hm2

• Allelic Composition: Ehmt1^{tm1b(EUCOMM)Hmgu}/Ehmt1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ehmt1^{tm1b(EUCOMM)Hmgu}/Wtsi
• Cell Lines: HEPD0734_3_F01

Data Sources

IMPC Data for Ehmt1

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:5757034

ht3

• Allelic Composition: Ehmt1^{tm1b(EUCOMM)Hmgu}/Ehmt1⁺
• Genetic Background: C57BL/6N-Ehmt1^{tm1b(EUCOMM)Hmgu}/Nju
• Cell Lines: HEPD0734_3_F01

Data Sources

IMPC Data for Ehmt1

behavior/neurological

abnormal behavior ( J:211773 )

♀

IMPC - MARC

decreased exploration in new environment ( J:211773 )

♀

IMPC - MARC

increased anxiety-related response ( J:211773 )

♀

IMPC - MARC

increased thigmotaxis ( J:211773 )

♀

IMPC - MARC

impaired pupillary reflex ( J:211773 )

♀

IMPC - MARC

increased grip strength ( J:211773 )

♀

IMPC - MARC

decreased locomotor activity ( J:211773 )

IMPC - MARC

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

♀

IMPC - MARC

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - MARC

growth/size/body

increased lean body mass ( J:211773 )

♂

IMPC - MARC

hematopoietic system

increased neutrophil cell number ( J:211773 )

♂

IMPC - MARC

increased mean platelet volume ( J:211773 )

♂

IMPC - MARC

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♂

IMPC - MARC

decreased blood urea nitrogen level ( J:211773 )

♂

IMPC - MARC

decreased circulating serum albumin level ( J:211773 )

♂

IMPC - MARC

immune system

increased neutrophil cell number ( J:211773 )

♂

IMPC - MARC

nervous system

abnormal optic disk morphology ( J:211773 )

♀

IMPC - MARC

vision/eye

impaired pupillary reflex ( J:211773 )

♀

IMPC - MARC

abnormal retina vasculature morphology ( J:211773 )

♀

IMPC - MARC

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - MARC

abnormal optic disk morphology ( J:211773 )

♀

IMPC - MARC

abnormal iris morphology ( J:211773 )

♀

IMPC - MARC

irregularly shaped pupil ( J:211773 )

♀

IMPC - MARC

cornea opacity ( J:211773 )

♀

IMPC - MARC

persistence of hyaloid vascular system ( J:211773 )

♀

IMPC - MARC

Genotype
MGI:6262348

ht4

• Allelic Composition: Ehmt1^{tm1b(EUCOMM)Hmgu}/Ehmt1⁺
• Genetic Background: C57BL/6N-Ehmt1^{tm1b(EUCOMM)Hmgu}/Wtsi
• Cell Lines: HEPD0734_3_F01

Data Sources

IMPC Data for Ehmt1

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♂

IMPC - WTSI

increased circulating LDL cholesterol level ( J:211773 )

♂

IMPC - WTSI