All Phenotypes Wnt5a<tm1.1Krvl> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wnt5a^tm1.1Krvl
targeted mutation 1.1, Rejji Kuruvilla
MGI:5605689

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt5a^tm1.1Krvl/Wnt5a^tm1.1Krvl	involves: 129S6/SvEvTac * C57BL/6	MGI:5605988
cn2	Wnt5a^tm1Amc/Wnt5a^tm1.1Krvl H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J	MGI:5605991
cn3	Wnt5a^tm1.1Krvl/Wnt5a^tm1.1Krvl Tg(Th-cre)#Gsat/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5607432

Allelic Composition	Wnt5a^tm1.1Krvl/Wnt5a^tm1.1Krvl
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt5a^tm1.1Krvl mutation (1 available); any Wnt5a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:196291 )

• mice are viable and fertile

Allelic Composition	Wnt5a^tm1Amc/Wnt5a^tm1.1Krvl H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Wnt5a^tm1.1Krvl mutation (1 available); any Wnt5a mutation (40 available)
Wnt5a^tm1Amc mutation (1 available); any Wnt5a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:196291 )

• pups die within a few hours of birth

nervous system

increased neuron apoptosis ( J:196291 )

• increased neuron apoptosis observed in superior cervical ganglia

abnormal axon extension ( J:196291 )

• defects in extension and branching of sympathetic axons are observed in salivary glands, thymus, heart, spleen and bladder at E16.5

abnormal sympathetic neuron innervation pattern ( J:196291 )

• incomplete innervation in paravertebral sympathetic ganglia and prevertebral ganglia

• sympathetic axons in spleen extend to target, but fail to grow and arborize spleen parenchyma

craniofacial

abnormal craniofacial morphology ( J:196291 )

• pups exhibit craniofacial abnormalities

cellular

increased neuron apoptosis ( J:196291 )

• increased neuron apoptosis observed in superior cervical ganglia

abnormal axon extension ( J:196291 )

• defects in extension and branching of sympathetic axons are observed in salivary glands, thymus, heart, spleen and bladder at E16.5

Allelic Composition	Wnt5a^tm1.1Krvl/Wnt5a^tm1.1Krvl Tg(Th-cre)#Gsat/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Th-cre)#Gsat mutation (0 available)
Wnt5a^tm1.1Krvl mutation (1 available); any Wnt5a mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal superior cervical ganglion morphology ( J:196291 )

abnormal sympathetic neuron innervation pattern ( J:196291 )

• reduced innervation of peripheral tissues

decreased neuron number ( J:196291 )

• 30% decrease in numbers of superior cervical ganglia neurons by P7

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23