Phenotypes associated with this allele

• Allele Symbol: Bhlha9^tm1Nba
• Allele Name: targeted mutation 1, Nissim Ben-Arie
• Allele ID: MGI:5604430
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bhlha9^tm1Nba/Bhlha9^tm1Nba	involves: 129S/SvEv * C57BL/6 * C57BL/6N	MGI:5604435

Genotype
MGI:5604435

hm1

• Allelic Composition: Bhlha9^tm1Nba/Bhlha9^tm1Nba
• Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal interdigital cell death ( J:214852 )

• hand pads show various levels of reduced apoptosis between digits 2 and 3

syndactyly ( J:214852 )

• various degrees of soft tissue syndactyly, with an incomplete separation of digits 2-3, the index and middle fingers, in the forelimbs

• penetrance of syndactyly is 93%, although severity is highly variable, with about 40% of mice showing syndactyly in both forelimbs, 29% only in the left, 25% only in the right and 7% are normal

• in males, 46% of adults show syndactyly only in the left forelimb

• in females, 48% of adults show syndactyly in both forelimbs

• incomplete separation of forelimb digits 2-3 is seen as early as E14.5

• skeletal abnormalities are not seen in the hand plates or arms

interdigital webbing ( J:214852 )

• 3 mice show webbing of hindlimbs fingers 2-3, or forelimb fingers 3-4 or 2-3-4

cellular

abnormal interdigital cell death ( J:214852 )

• hand pads show various levels of reduced apoptosis between digits 2 and 3