Phenotypes associated with this allele

• Allele Symbol: Stat1^tm2.1Uvin
• Allele Name: targeted mutation 2.1, Uwe Vinkemeier
• Allele ID: MGI:5588365
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stat1^tm2.1Uvin/Stat1^tm2.1Uvin	B6.129P2-Stat1^tm2.1Uvin	MGI:5588366

Genotype
MGI:5588366

hm1

• Allelic Composition: Stat1^tm2.1Uvin/Stat1^tm2.1Uvin
• Genetic Background: B6.129P2-Stat1^tm2.1Uvin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:209388 )

• in mice infected with Listeria monocytogenes

immune system

immune system phenotype ( J:209388 )

N • mice exhibit normal type 1 IFN-dominated response to vesicular stomatitis virus

decreased susceptibility to endotoxin shock ( J:209388 )

• moderately

increased susceptibility to bacterial infection ( J:209388 )

• macrophages treated with IFN-gamma fail to reduced bacterial titers of Listeria monocytogenes unlike wild-type cells

increased susceptibility to bacterial infection induced morbidity/mortality ( J:209388 )

• in mice infected with Listeria monocytogenes