Stat1^tm2.1Uvin
Targeted Allele Detail

Summary

• Symbol: Stat1^tm2.1Uvin
• Name: signal transducer and activator of transcription 1; targeted mutation 2.1, Uwe Vinkemeier
• MGI ID: MGI:5588365
• Synonyms: STAT1^F77A
• Gene: Stat1 Location: Chr1:52158599-52201024 bp, + strand Genetic Position: Chr1, 26.81 cM
• Alliance: Stat1^tm2.1Uvin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209388
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 4 was replaced with a modified exon 4 in which nucleotide substitutions (GAA to GGC) result in the amino acid substitution of alanine for phenylalanine at position 77 (F77A). This mutation abolishes DNA-dependent cooperative multimerization. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon. (J:209388)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat1 Mutation: 73 strains or lines available

References

• Original: J:209388 Begitt A, et al., STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling. Nat Immunol. 2014 Feb;15(2):168-76
• All: 2 reference(s)