Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-Aimp1)29872Mcla
• Allele Name: transgene insertion 29872, Matthias Clauss
• Allele ID: MGI:5587972
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-Aimp1)29872Mcla/0	involves: 129 * C57BL/6	MGI:5604244

Genotype
MGI:5604244

cx1

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-Aimp1)29872Mcla/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased lung endothelial cell apoptosis ( J:173904 )

• 3 fold increase in caspase 3 activity in lung alveolar cells is measured as early as 4 weeks after doxycycline (dox) induction

hematopoietic system

increased macrophage cell number ( J:173904 )

• 28 weeks of doxycycline induction results in an increase in the number of alveolar macrophages in bronchoalveolar lavage fluid (BALF) and lung parenchyma from lung lysates

immune system

increased macrophage cell number ( J:173904 )

• 28 weeks of doxycycline induction results in an increase in the number of alveolar macrophages in bronchoalveolar lavage fluid (BALF) and lung parenchyma from lung lysates

respiratory system

increased lung endothelial cell apoptosis ( J:173904 )

• 3 fold increase in caspase 3 activity in lung alveolar cells is measured as early as 4 weeks after doxycycline (dox) induction

abnormal pulmonary acinus morphology ( J:173904 )

• increase in diameters of acinar airspaces (comprising alveolar ducts and alveoli) following dox treatment as compared to controls

dilated pulmonary alveolar duct ( J:173904 )

• following doxycycline induction

overexpanded pulmonary alveolus ( J:173904 )

• following doxycycline induction

emphysema ( J:173904 )

• following doxycycline induction