About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prmt1tm1c(EUCOMM)Wtsi
targeted mutation 1c, Welcome Trust Sanger Institute
MGI:5587827
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Prmt1tm1c(EUCOMM)Wtsi/Prmt1+
Rb1tm3Tyj/Rb1tm3Tyj
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CD-1 MGI:7486124


Genotype
MGI:7486124
cn1
Allelic
Composition		 Prmt1tm1c(EUCOMM)Wtsi/Prmt1+
Rb1tm3Tyj/Rb1tm3Tyj
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prmt1tm1c(EUCOMM)Wtsi mutation (1 available); any Prmt1 mutation (35 available)
Rb1tm3Tyj mutation (10 available); any Rb1 mutation (107 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:245660 )
• mice begin to die at ~100 days of age and all die by around 200 days of age, with a median survival similar to that of mutant mice homozygous for the wild-type Prmt1 allele

neoplasm
increased osteosarcoma incidence ( J:245660 )
• microPET/CT imaging suggested an increase in the presence of osteosarcomas at 100 days of age

skeleton
increased osteosarcoma incidence ( J:245660 )
• microPET/CT imaging suggested an increase in the presence of osteosarcomas at 100 days of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory