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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hormad1tm1Kura
targeted mutation 1, Hiroki Kurahashi
MGI:5587823
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hormad1tm1Kura/Hormad1tm1Kura either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj) MGI:5587824
cx2
Hormad1tm1Kura/Hormad1tm1Kura
Spo11tm1Mjn/Spo11tm1Mjn
involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj MGI:5587825


Genotype
MGI:5587824
hm1
Allelic
Composition
Hormad1tm1Kura/Hormad1tm1Kura
Genetic
Background
either: B6.Cg-Hormad1tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad1tm1Kura mutation (1 available); any Hormad1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• ovary weight and oocyte apoptosis are normal
• non-homologous chromosome synapsis in spermatocytes and oocytes
• most chromosomes are univalent with few bivalent resulting in aneuloidy
• few or partial synapsis are observed and some
• absence of diplotene stage spermatocytes due to apoptosis
• absence of diplotene stage spermatocytes due to apoptosis
• one third of wild-type

cellular
• in oocyte
• non-homologous chromosome synapsis in spermatocytes and oocytes
• most chromosomes are univalent with few bivalent resulting in aneuloidy
• few or partial synapsis are observed and some
• absence of diplotene stage spermatocytes due to apoptosis
• absence of diplotene stage spermatocytes due to apoptosis
• decreased or absent double strand DNA break formation in spermatocytes
• no embryos are observed at implantation sites due to aneuploidy
• however, some oocytes are capable of fertilization and implantation

endocrine/exocrine glands
• one third of wild-type

homeostasis/metabolism
• decreased or absent double strand DNA break formation in spermatocytes




Genotype
MGI:5587825
cx2
Allelic
Composition
Hormad1tm1Kura/Hormad1tm1Kura
Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background
involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad1tm1Kura mutation (1 available); any Hormad1 mutation (31 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• oocyte cell death observed in Spo11 null mice is abrogated
• oocytes lack pseudo sex bodies
• spermatocytes from stage IV seminiferous tubules is reduced
• however, spermatocytes from stages I to III seminiferous tubules form pseudo sex bodies
• apoptotic cells at the pachytene stage

cellular
• oocytes lack pseudo sex bodies
• spermatocytes from stage IV seminiferous tubules is reduced
• however, spermatocytes from stages I to III seminiferous tubules form pseudo sex bodies
• apoptotic cells at the pachytene stage





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory