All Phenotypes Hormad1<tm1Kura> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hormad1^tm1Kura/Hormad1^tm1Kura	either: B6.Cg-Hormad1^tm1Kura or (involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj)	MGI:5587824
cx2	Hormad1^tm1Kura/Hormad1^tm1Kura Spo11^tm1Mjn/Spo11^tm1Mjn	involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj	MGI:5587825

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:213984 )

N	• ovary weight and oocyte apoptosis are normal

azoospermia ( J:213984 )

abnormal chromosomal synapsis ( J:213984 )

• non-homologous chromosome synapsis in spermatocytes and oocytes

abnormal female meiosis ( J:213984 )

• most chromosomes are univalent with few bivalent resulting in aneuloidy

abnormal male meiosis ( J:213984 )

• few or partial synapsis are observed and some

arrest of male meiosis ( J:213984 )

• absence of diplotene stage spermatocytes due to apoptosis

abnormal male germ cell apoptosis ( J:213984 )

• absence of diplotene stage spermatocytes due to apoptosis

decreased testis weight ( J:213984 )

• one third of wild-type

male infertility ( J:213984 )

cellular

azoospermia ( J:213984 )

aneuploidy ( J:213984 )

• in oocyte

abnormal chromosomal synapsis ( J:213984 )

• non-homologous chromosome synapsis in spermatocytes and oocytes

abnormal female meiosis ( J:213984 )

• most chromosomes are univalent with few bivalent resulting in aneuloidy

abnormal male meiosis ( J:213984 )

• few or partial synapsis are observed and some

arrest of male meiosis ( J:213984 )

• absence of diplotene stage spermatocytes due to apoptosis

abnormal male germ cell apoptosis ( J:213984 )

• absence of diplotene stage spermatocytes due to apoptosis

abnormal DNA repair ( J:213984 )

• decreased or absent double strand DNA break formation in spermatocytes

maternal effect ( J:213984 )

• no embryos are observed at implantation sites due to aneuploidy

• however, some oocytes are capable of fertilization and implantation

endocrine/exocrine glands

decreased testis weight ( J:213984 )

• one third of wild-type

homeostasis/metabolism

abnormal DNA repair ( J:213984 )

• decreased or absent double strand DNA break formation in spermatocytes

Allelic Composition	Hormad1^tm1Kura/Hormad1^tm1Kura Spo11^tm1Mjn/Spo11^tm1Mjn
Genetic Background	involves: 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad1^tm1Kura mutation (1 available); any Hormad1 mutation (31 available)
Spo11^tm1Mjn mutation (2 available); any Spo11 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:213984 )

N	• oocyte cell death observed in Spo11 null mice is abrogated

abnormal female meiosis ( J:213984 )

• oocytes lack pseudo sex bodies

abnormal male meiosis ( J:213984 )

• spermatocytes from stage IV seminiferous tubules is reduced

• however, spermatocytes from stages I to III seminiferous tubules form pseudo sex bodies

abnormal male germ cell apoptosis ( J:213984 )

• apoptotic cells at the pachytene stage

cellular

abnormal female meiosis ( J:213984 )

• oocytes lack pseudo sex bodies

abnormal male meiosis ( J:213984 )

• spermatocytes from stage IV seminiferous tubules is reduced

• however, spermatocytes from stages I to III seminiferous tubules form pseudo sex bodies

abnormal male germ cell apoptosis ( J:213984 )

• apoptotic cells at the pachytene stage

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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