Phenotypes associated with this allele

• Allele Symbol: P3h2^tm1Hpb
• Allele Name: targeted mutation 1, Hans Peter Bachinger
• Allele ID: MGI:5585628
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	P3h2^tm1Hpb/P3h2^tm1Hpb	involves: 129 * C57BL/6J	MGI:5585630
cx2	Gp6^tm1Ware/Gp6^+ P3h2^tm1Hpb/P3h2^tm1Hpb	involves: 129 * Black Swiss * C57BL/6J	MGI:5585632
cx3	Gp6^tm1Ware/Gp6^tm1Ware P3h2^tm1Hpb/P3h2^tm1Hpb	involves: 129 * Black Swiss * C57BL/6J	MGI:5585633

Genotype
MGI:5585630

hm1

• Allelic Composition: P3h2^tm1Hpb/P3h2^tm1Hpb
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Maternal blood invades the ectoplacental cone of E6.5 P3h2^tm1Hpb/P3h2^tm1Hpb embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:206377 )

• no mice are recovered at E12.5

embryonic lethality, incomplete penetrance ( J:206377 )

• fewer than expected mice are present at between E11.5 and E8.5

homeostasis/metabolism

abnormal thrombosis ( J:206377 )

• blood clots at E6.5

• maternal platelets aggregate around the ectoplacental cone

Genotype
MGI:5585632

cx2

• Allelic Composition: Gp6^tm1Ware/Gp6⁺; P3h2^tm1Hpb/P3h2^tm1Hpb
• Genetic Background: involves: 129 * Black Swiss * C57BL/6J

mortality/aging

prenatal lethality, complete penetrance ( J:206377 )

• although present at E8.5, no mice are present at birth

Genotype
MGI:5585633

cx3

• Allelic Composition: Gp6^tm1Ware/Gp6^tm1Ware; P3h2^tm1Hpb/P3h2^tm1Hpb
• Genetic Background: involves: 129 * Black Swiss * C57BL/6J

mortality/aging

mortality/aging ( J:206377 )

N • mice are born in expected Mendelian ratios and survive to adulthood