Analysis Tools
cardiovascular system
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• tamoxifen-treated mice exhibit decreased radial length, vascular density, endothelial cell proliferative activity, sprouting activity, and pericyte coverage compared with control mice
• tamoxifen-treated mice exhibit decreased vascular density in the superficial and deep vascular plexus layers compared with control mice
• tamoxifen-treated mice exhibit disorganized, regressed, disconnected and dilated retinal vessels compared with control mice
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• 4-fold increased vessel leakage following oxygen-induced retinopathy in tamoxifen-treated mice
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vision/eye
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• tamoxifen-treated mice exhibit decreased radial length, vascular density, endothelial cell proliferative activity, sprouting activity, and pericyte coverage compared with control mice
• tamoxifen-treated mice exhibit decreased vascular density in the superficial and deep vascular plexus layers compared with control mice
• tamoxifen-treated mice exhibit disorganized, regressed, disconnected and dilated retinal vessels compared with control mice
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• following oxygen-induced retinopathy, mice exhibit increased avascular area, neovascular tuft area and reduced pericyte coverage in the superficial layer with disorganized, regressed, disconnected and dilated deep layer vessels, 4-fold increased vessel leakage and 4-fold increase in multifocal hemorrhages compared with control mice
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nervous system
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• decrease in GFAP+ cell densities in tamoxifen-treated mice
• however, the number of Pax2+ astrocytes is normal
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homeostasis/metabolism
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• following oxygen-induced retinopathy, mice exhibit increased avascular area, neovascular tuft area and reduced pericyte coverage in the superficial layer with disorganized, regressed, disconnected and dilated deep layer vessels, 4-fold increased vessel leakage and 4-fold increase in multifocal hemorrhages compared with control mice
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