Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-Ago2)30Mnpy
• Allele Name: transgene insertion 30, Matthew N Poy
• Allele ID: MGI:5585175
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Ins2-rtTA)2Efr/0 Tg(tetO-Ago2)30Mnpy/0	involves: C57BL/6 * CBA	MGI:5585183

Genotype
MGI:5585183

cx1

• Allelic Composition: Tg(Ins2-rtTA)2Efr/0; Tg(tetO-Ago2)30Mnpy/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreatic beta cell proliferation ( J:210552 )

• in doxycycline-treated mice

increased pancreatic beta cell mass ( J:210552 )

• in doxycycline-treated mice

increased pancreatic beta cell number ( J:210552 )

• in doxycycline-treated mice

decreased insulin secretion ( J:210552 )

• doxycycline-treated mice exhibit reduced acute-phase plasma insulin release compared with control mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:210552 )

N • doxycycline-treated mice exhibit normal insulin sensitivity after glucose challenge

decreased insulin secretion ( J:210552 )

• doxycycline-treated mice exhibit reduced acute-phase plasma insulin release compared with control mice

increased circulating glucose level ( J:210552 )

• transient after glucose challenge in doxycycline-treated mice

cellular

increased pancreatic beta cell proliferation ( J:210552 )

• in doxycycline-treated mice