All Phenotypes Poli<tm1.1Lgh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Poli^tm1.1Lgh
targeted mutation 1.1, Gang-Hong Lee
MGI:5582769

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Par2^A/J/? Poli^tm1.1Lgh/Poli⁺	involves: A/J * C57BL/6J	MGI:5582777
cx2	Pas17^C57BL/6JBy/Pas17^C57BL/6JBy Poli^tm1.1Lgh/Poli⁺	involves: C57BL/6J	MGI:5582778
cx3	Pas17^C57BL/6JBy/Pas17^C57BL/6JBy Poli^tm1.1Lgh/Poli^tm1.1Lgh	involves: C57BL/6J	MGI:5582779
cx4	Poli^tm1.1Lgh/Poli^tm1.1Lgh Tg(gptdelta)1Nmi/0	involves: C57BL/6J	MGI:5582780

Allelic Composition	Par2^A/J/? Poli^tm1.1Lgh/Poli⁺
Genetic Background	involves: A/J * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Par2^A/J mutation (0 available); any Par2 mutation (1 available)
Poli^tm1.1Lgh mutation (0 available); any Poli mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:212610 )

• 1.7-fold increase in tumor number induced by urethane compared with control mice

• however, tumor size is normal

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:212610 )

• 1.7-fold increase in tumor number induced by urethane compared with control mice

• however, tumor size is normal

Allelic Composition	Pas17^C57BL/6JBy/Pas17^C57BL/6JBy Poli^tm1.1Lgh/Poli⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pas17^C57BL/6JBy mutation (0 available); any Pas17 mutation (0 available)
Poli^tm1.1Lgh mutation (0 available); any Poli mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:212610 )

• intermediate increase in tumor number induced by urethane

• however, tumor size is normal

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:212610 )

• intermediate increase in tumor number induced by urethane

• however, tumor size is normal

Allelic Composition	Pas17^C57BL/6JBy/Pas17^C57BL/6JBy Poli^tm1.1Lgh/Poli^tm1.1Lgh
Genetic Background	involves: C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:212610 )

• increase in tumor number induced by urethane that is not as severe as in mice heterozygous for Par2^A/J, Poli^tm1Lgh, and Pas1^A/J/Pas1^C57BL/6J

• however, tumor size is normal

cellular

abnormal cell physiology ( J:212610 )

• increased urethane-induced DNA mutations in Kras

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:212610 )

• however, tumor size is normal

• increase in tumor number induced by urethane that is not as severe as in mice heterozygous for Par2^A/J, Poli^tm1Lgh, and Pas1^A/J/Pas1^C57BL/6J

Allelic Composition	Poli^tm1.1Lgh/Poli^tm1.1Lgh Tg(gptdelta)1Nmi/0
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Poli^tm1.1Lgh mutation (0 available); any Poli mutation (45 available)
Tg(gptdelta)1Nmi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:212610 )

N	• mice exhibit normal spontaneous tumor rates

increased incidence of tumors by chemical induction ( J:212610 )

• 1.8 times greater than in Tg(gptdelta)1Nmi mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:212610 )

• 1.8 times greater than in Tg(gptdelta)1Nmi mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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