Phenotypes associated with this allele

• Allele Symbol: Ifi27^tm1Npm
• Allele Name: targeted mutation 1, Nikolina Papac-Milicevic
• Allele ID: MGI:5582315
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifi27^tm1Npm/Ifi27^tm1Npm	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster	MGI:5582317
cx2	Ifi27^tm1Npm/Ifi27^tm1Npm Nr4a1^tm1Jmi/Nr4a1^tm1Jmi	involves: 129 * C57BL/6 * Swiss Webster	MGI:5582318

Genotype
MGI:5582317

hm1

• Allelic Composition: Ifi27^tm1Npm/Ifi27^tm1Npm
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:212520 )

N • under basal conditions, vascular morphology is normal

abnormal vascular wound healing ( J:212520 )

• following carotid artery ligation, mice retain a larger lumen area than in wild-type mice with only negligible neointima formation

• following, femoral artery cuff model, mice exhibit reduced neointima formation compared with wild-type mice

• mice are protected against induced restenosis compared with wild-type mice

homeostasis/metabolism

abnormal vascular wound healing ( J:212520 )

• following carotid artery ligation, mice retain a larger lumen area than in wild-type mice with only negligible neointima formation

• following, femoral artery cuff model, mice exhibit reduced neointima formation compared with wild-type mice

• mice are protected against induced restenosis compared with wild-type mice

Genotype
MGI:5582318

cx2

• Allelic Composition: Ifi27^tm1Npm/Ifi27^tm1Npm; Nr4a1^tm1Jmi/Nr4a1^tm1Jmi
• Genetic Background: involves: 129 * C57BL/6 * Swiss Webster

cardiovascular system

cardiovascular system phenotype ( J:212520 )

N • mice exhibit normal induced restenosis