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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good
targeted mutation 1, Lisa Goodrich
MGI:5581667
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm2Gsv
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5581690
cn2
 		Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Tg(Neurog1-cre)1Jejo/0 		involves: 129S4/SvJae * C57BL/6J * SJL/J MGI:5581688


Genotype
MGI:5581690
cn1
Allelic
Composition		 Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm2Gsv
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm3.1(cre)Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (31 available)
Gata3tm2Gsv mutation (0 available); any Gata3 mutation (31 available)
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• partial rescue of ribbon loss observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice
abnormal cochlear ganglion morphology ( J:207904 )
• partial rescue of synaptic defects observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice

hearing/vestibular/ear
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• partial rescue of ribbon loss observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice




Genotype
MGI:5581688
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Tg(Neurog1-cre)1Jejo/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Neurog1-cre)1Jejo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:207904 )
• most mice die at 3 weeks of age of unknown causes

nervous system
nervous system phenotype ( J:207904 )
N
• cochlear wiring and in spiral ganglion neuron firing properties are normal
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• precocious basolateral localization of pre-synaptic ribbons in the hair cells
• however, the number of ribbons is normal
abnormal cochlear ganglion morphology ( J:207904 )
• afferent synapse development is accelerated in spiral ganglion neuron compared to in control mice

hearing/vestibular/ear
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• precocious basolateral localization of pre-synaptic ribbons in the hair cells
• however, the number of ribbons is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory