Phenotypes associated with this allele

• Allele Symbol: Stk11^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5578333
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk11^tm1.1Arte/Stk11^tm1.1Arte	involves: C57BL/6J	MGI:5578343

Genotype
MGI:5578343

hm1

• Allelic Composition: Stk11^tm1.1Arte/Stk11^tm1.1Arte
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:208379 )

N • mice exhibit normal viability

reproductive system

reproductive system phenotype ( J:208379 )

N • mice exhibit normal fertility

cellular

abnormal cell physiology ( J:208379 )

• impaired contraction-induced AMPK activation in muscle cells

• impaired basal-, AICAR- and phenformin-induced AMPK activation in mouse embryonic fibroblasts

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208379 )

N • mice exhibit normal glucose tolerance

abnormal lipid homeostasis ( J:208379 )

• reduced ability of AICAR to impair lipid synthesis in primary hepatocytes

muscle

abnormal muscle physiology ( J:208379 )

• impaired contraction-induced AMPK activation in muscle cells