Stk11^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Stk11^tm1.1Arte
• Name: serine/threonine kinase 11; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5578333
• Synonyms: LKB1^C433S
• Gene: Stk11 Location: Chr10:79951637-79966516 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Stk11^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208379
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 9 was replaced with a frt-flanked puromycin resistance cassette and a modified exon 9 in which nucleotide substitution(s) result(s) in the amino acid substitution of serine for cysteine at position 433 (C433S). This mutation abolishes the prenylation at the site. Flp-mediated recombination removed the selection cassette. (J:208379)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk11 Mutation: 34 strains or lines available

References

• Original: J:208379 Houde VP, et al., Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. Biochem J. 2014 Feb 15;458(1):41-56
• All: 1 reference(s)