All Phenotypes Tbc1d10c<tm1.1Psou> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tbc1d10c^tm1.1Psou
targeted mutation 1.1, Pauline Soulas-Sprauel
MGI:5578033

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tbc1d10c^tm1.1Psou/Tbc1d10c^tm1.2Psou Cd79a^tm1(cre)Reth/Cd79a⁺	involves: 129S2/SvPas * BALB/c * C57BL/6J	MGI:5578118
cn2	Tbc1d10c^tm1.1Psou/Tbc1d10c^tm1.2Psou Tg(Lck-cre)#Nik/0	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * DBA/2	MGI:5578119

Allelic Composition	Tbc1d10c^tm1.1Psou/Tbc1d10c^tm1.2Psou Cd79a^tm1(cre)Reth/Cd79a⁺
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (22 available)
Tbc1d10c^tm1.1Psou mutation (1 available); any Tbc1d10c mutation (19 available)
Tbc1d10c^tm1.2Psou mutation (1 available); any Tbc1d10c mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:211913 )

• accelerated antigen-specific B cell response in vivo in response to ovalbumin

increased IgG level ( J:211913 )

• increased anti-ovalbumin IgG titer after ovalbumin treatment

• CpG-DNA-treated mice exhibit renal IgG deposits unlike wild-type mice

increased IgM level ( J:211913 )

• in ovalbumin-treated mice

increased susceptibility to systemic lupus erythematosus ( J:211913 )

• CpG-DNA-treated mice exhibit increased anti-double stranded DNA antibody levels and renal IgG deposits compared with control mice

increased anti-double stranded DNA antibody level ( J:211913 )

• in CpG-DNA-treated mice

• however, untreated mice do not produce autoantibodies

hematopoietic system

abnormal B cell physiology ( J:211913 )

• accelerated antigen-specific B cell response in vivo in response to ovalbumin

increased IgG level ( J:211913 )

• increased anti-ovalbumin IgG titer after ovalbumin treatment

• CpG-DNA-treated mice exhibit renal IgG deposits unlike wild-type mice

increased IgM level ( J:211913 )

• in ovalbumin-treated mice

Allelic Composition	Tbc1d10c^tm1.1Psou/Tbc1d10c^tm1.2Psou Tg(Lck-cre)#Nik/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbc1d10c^tm1.1Psou mutation (1 available); any Tbc1d10c mutation (19 available)
Tbc1d10c^tm1.2Psou mutation (1 available); any Tbc1d10c mutation (19 available)
Tg(Lck-cre)#Nik mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:211913 )

N	• mice exhibit normal early antigen-specific B cell response

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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