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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc1a2tm1.1Ncd
targeted mutation 1.1, NC Danbolt
MGI:5576462
Summary 3 genotypes


Genotype
MGI:5576470
cn1
Allelic
Composition		 Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 B6.Cg-Slc1a2tm1.1Ncd Tg(Ins2-cre)25Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc1a2tm1.1Ncd mutation (1 available); any Slc1a2 mutation (40 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:207177 )
• mice show normal body weights and appearance and show no differences in glucose tolerance




Genotype
MGI:5576464
cn2
Allelic
Composition		 Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd
Tg(Nes-cre)1Kln/0
Genetic
Background		 B6.Cg-Slc1a2tm1.1Ncd Tg(Nes-cre)1Kln
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc1a2tm1.1Ncd mutation (1 available); any Slc1a2 mutation (40 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:207177 )
• 50% survival after 8 weeks
premature death ( J:207177 )
• higher mortality rate after 3 weeks, with only 50% survival after 8 weeks

growth/size/body
slow postnatal weight gain ( J:207177 )

behavior/neurological
hyperactivity ( J:207177 )
• mice become hyperactive after about 2 weeks
seizures ( J:207177 )
• spontaneous seizures are seen after about 2 weeks

nervous system
seizures ( J:207177 )
• spontaneous seizures are seen after about 2 weeks




Genotype
MGI:5576472
cn3
Allelic
Composition		 Slc1a2tm1.1Ncd/Slc1a2tm1.1Ncd
Tg(Pdx1-cre)1Heed/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc1a2tm1.1Ncd mutation (1 available); any Slc1a2 mutation (40 available)
Tg(Pdx1-cre)1Heed mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:207177 )
• mice show normal body weights and appearance and show no differences in glucose tolerance




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory