Phenotypes associated with this allele

• Allele Symbol: Slc1a2^tm1.1Ncd
• Allele Name: targeted mutation 1.1, NC Danbolt
• Allele ID: MGI:5576462
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Slc1a2^tm1.1Ncd/Slc1a2^tm1.1Ncd Tg(Ins2-cre)25Mgn/0	B6.Cg-Slc1a2^tm1.1Ncd Tg(Ins2-cre)25Mgn	MGI:5576470
cn2	Slc1a2^tm1.1Ncd/Slc1a2^tm1.1Ncd Tg(Nes-cre)1Kln/0	B6.Cg-Slc1a2^tm1.1Ncd Tg(Nes-cre)1Kln	MGI:5576464
cn3	Slc1a2^tm1.1Ncd/Slc1a2^tm1.1Ncd Tg(Pdx1-cre)1Heed/0	involves: 129S6/SvEvTac * C57BL/6J	MGI:5576472

Genotype
MGI:5576470

cn1

• Allelic Composition: Slc1a2^tm1.1Ncd/Slc1a2^tm1.1Ncd; Tg(Ins2-cre)25Mgn/0
• Genetic Background: B6.Cg-Slc1a2^tm1.1Ncd Tg(Ins2-cre)25Mgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:207177 )

• mice show normal body weights and appearance and show no differences in glucose tolerance

Genotype
MGI:5576464

cn2

• Allelic Composition: Slc1a2^tm1.1Ncd/Slc1a2^tm1.1Ncd; Tg(Nes-cre)1Kln/0
• Genetic Background: B6.Cg-Slc1a2^tm1.1Ncd Tg(Nes-cre)1Kln

mortality/aging

decreased survivor rate ( J:207177 )

• 50% survival after 8 weeks

premature death ( J:207177 )

• higher mortality rate after 3 weeks, with only 50% survival after 8 weeks

growth/size/body

slow postnatal weight gain ( J:207177 )

behavior/neurological

hyperactivity ( J:207177 )

• mice become hyperactive after about 2 weeks

seizures ( J:207177 )

• spontaneous seizures are seen after about 2 weeks

nervous system

seizures ( J:207177 )

• spontaneous seizures are seen after about 2 weeks

Genotype
MGI:5576472

cn3

• Allelic Composition: Slc1a2^tm1.1Ncd/Slc1a2^tm1.1Ncd; Tg(Pdx1-cre)1Heed/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:207177 )

• mice show normal body weights and appearance and show no differences in glucose tolerance