Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbpm1H mutation
(1 available);
any
Tardbp mutation
(60 available)
|
|
|
Allelic Composition |
Tardbpm1H/Tardbp+
|
|
Genetic Background |
involves: C3H/HeH * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbpm1H mutation
(1 available);
any
Tardbp mutation
(60 available)
|
|
|
muscle
|
• in the extensor digitorum longus
|
|
• soft abdominal body tone in male and female mice
|
behavior/neurological
|
• in female at 61 weeks
• however, male mice did not exhibit this phenotype but were not assessed beyond 52 weeks of age
|
nervous system
N |
• mice exhibit normal neuromuscular junctions in the abdomen and hindlimbs
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbpm1H mutation
(1 available);
any
Tardbp mutation
(60 available)
Tg(SOD1*G93A)1Gur mutation
(4 available)
|
|
|
mortality/aging
|
• as in Tg(SOD1*G93A)1Gur mice
|
muscle
|
• compared with Tg(SOD1*G93A)1Gur mice
|
|
• in the tibialis anterior compared with Tg(SOD1*G93A)1Gur mice
• however, relaxation time in the extensor digitorum longus is normal
|
|
• soft abdominal body tone as in Tardbpm1H heterozygotes
|
behavior/neurological
|
• as in Tg(SOD1*G93A)1Gur mice
|
growth/size/body
|
• as in Tg(SOD1*G93A)1Gur mice
|
nervous system
N |
• mice exhibit normal numbers of motor neurons in the sciatic motor pool
|
limbs/digits/tail
|
• compared with Tg(SOD1*G93A)1Gur mice
|