All Phenotypes Raph1<tm1.1Makr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Raph1^tm1.1Makr
targeted mutation 1.1, Matthias Krause
MGI:5575553

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Raph1^tm1.1Makr/Raph1^tm1.1Makr	involves: C57BL/6NTac	MGI:5575558
cn2	Raph1^tm1.1Makr/Raph1^tm1.1Makr Tg(Pgk1-cre)1Lni/0	involves: BALB/c * C57BL/6 * C57BL/6NTac	MGI:5575561
cn3	Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^{Tg(ACTB-cre)2Mrt}/0 Tg(Dct-lacZ)A12Jkn/Tg(Dct-lacZ)A12Jkn	involves: C57BL/6 * C57BL/6NTac * CBA * FVB/N	MGI:5575559
cn4	Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^{Tg(ACTB-cre)2Mrt}/0	involves: C57BL/6 * C57BL/6NTac * FVB/N	MGI:5575560

Allelic Composition	Raph1^tm1.1Makr/Raph1^tm1.1Makr
Genetic Background	involves: C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raph1^tm1.1Makr mutation (1 available); any Raph1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

impaired fibroblast cell migration ( J:208191 )

• in tamoxifen-treated mouse embryonic fibroblasts transduced with a retrovirus expressing an inducible cre

Allelic Composition	Raph1^tm1.1Makr/Raph1^tm1.1Makr Tg(Pgk1-cre)1Lni/0
Genetic Background	involves: BALB/c * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raph1^tm1.1Makr mutation (1 available); any Raph1 mutation (59 available)
Tg(Pgk1-cre)1Lni mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:208191 )

• Background Sensitivity: mice on a pure C57BL/6 genetic background (details not specified) tend to die shortly after birth unlike mice on a mixed background that are present in Mendelian ratios at P0

postnatal lethality, incomplete penetrance ( J:208191 )

• Background Sensitivity: fewer than expected mice on a mixed background are alive at P10 with many mice dying before 6 weeks of age

reproductive system

infertility ( J:208191 )

• Background Sensitivity: mice on a mixed background that reach sexual maturity are infertile

growth/size/body

decreased body size ( J:208191 )

pigmentation

belly spot ( J:208191 )

behavior/neurological

absent gastric milk in neonates ( J:208191 )

integument

belly spot ( J:208191 )

Allelic Composition	Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^{Tg(ACTB-cre)2Mrt}/0 Tg(Dct-lacZ)A12Jkn/Tg(Dct-lacZ)A12Jkn
Genetic Background	involves: C57BL/6 * C57BL/6NTac * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raph1^tm1.1Makr mutation (1 available); any Raph1 mutation (59 available)
Tg(Dct-lacZ)A12Jkn mutation (4 available)
Tmem163^{Tg(ACTB-cre)2Mrt} mutation (3 available); any Tmem163 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belly spot ( J:208191 )

decreased melanocyte number ( J:208191 )

• in the trunk region at E14.5

growth/size/body

decreased body size ( J:208191 )

integument

belly spot ( J:208191 )

Allelic Composition	Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^{Tg(ACTB-cre)2Mrt}/0
Genetic Background	involves: C57BL/6 * C57BL/6NTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raph1^tm1.1Makr mutation (1 available); any Raph1 mutation (59 available)
Tmem163^{Tg(ACTB-cre)2Mrt} mutation (3 available); any Tmem163 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced body size in Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^{Tg(ACTB-cre)2Mrt}/0 mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:208191 )

• some mice die within 4 weeks of birth

pigmentation

belly spot ( J:208191 )

growth/size/body

decreased body size ( J:208191 )

integument

belly spot ( J:208191 )

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