Raph1^tm1.1Makr
Targeted Allele Detail

Summary

• Symbol: Raph1^tm1.1Makr
• Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1; targeted mutation 1.1, Matthias Krause
• MGI ID: MGI:5575553
• Synonyms: Lpd^flox
• Gene: Raph1 Location: Chr1:60521451-60606263 bp, - strand Genetic Position: Chr1, 30.48 cM
• Alliance: Raph1^tm1.1Makr page

Reduced body size in Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^{Tg(ACTB-cre)2Mrt}/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208191
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exon 4 floxed. (J:208191)

Generation of the Raph1^tm1.1Makr allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Raph1 Mutation: 59 strains or lines available

References

• Original: J:208191 Law AL, et al., Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo. J Cell Biol. 2013 Nov 25;203(4):673-89
• All: 5 reference(s)