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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kif18atm1Zgwg
targeted mutation 1, Zhugang Wang
MGI:5575486
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kif18atm1Zgwg/Kif18atm1Zgwg either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J) MGI:5575488


Genotype
MGI:5575488
hm1
Allelic
Composition		 Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic
Background		 either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif18atm1Zgwg mutation (0 available); any Kif18a mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:211103 )
N
• epididymis morphology is normal
• ovary morphology is normal
increased male germ cell apoptosis ( J:211103 )
• mitotic arrest leads to apoptosis in seminiferous tubules
abnormal seminiferous tubule morphology ( J:211103 )
• single cell layer at 2 weeks
• growth arrest at 4 weeks with vacuolated and degenerative changes in the luminal side
• smaller numbers and hypocellular
seminiferous tubule degeneration ( J:211103 )
• at 4 weeks in the luminal side
• at 8 weeks
abnormal testis development ( J:211103 )
• developmental delay starting at 2 weeks
• underdeveloped at 8 weeks
increased Leydig cell number ( J:211103 )
• at 4 and 8 weeks
arrest of male meiosis ( J:211103 )
• more than 50% of testicular cells isolated at 8 weeks remain diploid
reduced female fertility ( J:211103 )
• slightly lower rate

cellular
abnormal mitosis ( J:211103 )
• impaired in seminiferous tubules with unaligned chromosomes
increased male germ cell apoptosis ( J:211103 )
• mitotic arrest leads to apoptosis in seminiferous tubules

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:211103 )
• single cell layer at 2 weeks
• growth arrest at 4 weeks with vacuolated and degenerative changes in the luminal side
• smaller numbers and hypocellular
seminiferous tubule degeneration ( J:211103 )
• at 4 weeks in the luminal side
• at 8 weeks
abnormal testis development ( J:211103 )
• developmental delay starting at 2 weeks
• underdeveloped at 8 weeks
increased Leydig cell number ( J:211103 )
• at 4 and 8 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory