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Allele Symbol Allele Name Allele ID |
Atp1a3tm1.1Kwk targeted mutation 1.1, Kiyoshi Kawakami MGI:5572809 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• due to lack of breathing movement
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• no breathing movement at birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal paired-pulse ratio and excitatory synaptic transmissions
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• response to electrical stimulation suggests decreased threshold of molecular layer interneurons
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• higher frequency compared to in wild-type Purkinje cells
• however, amplitude distribution and mean amplitude are normal
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• dystonic response to kainite injection is sustained longer with later recovery and larger D4/D5 response (number of events) than in wild-type mice
• however, the mean duration of individual events is normal
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• on a rotarod and a balance beam
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• in home cage and open field
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• dystonic response to kainite injection is sustained longer with later recovery and larger D4/D5 response (number of events) than in wild-type mice
• however, the mean duration of individual events is normal
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• dystonic response to kainite injection is sustained longer with later recovery and larger D4/D5 response (number of events) than in wild-type mice
• however, the mean duration of individual events is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/24/2023 MGI 6.22 |
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