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Targeted Allele Detail
Symbol: Atp1a3tm1.1Kwk
Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide; targeted mutation 1.1, Kiyoshi Kawakami
MGI ID: MGI:5572809
Gene: Atp1a3  Location: Chr7:24677592-24705383 bp, - strand  Genetic Position: Chr7, 13.73 cM
Alliance: Atp1a3tm1.1Kwk page
Germline Transmission:  Earliest citation of germline transmission: J:210870
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 through 6 were replaced with a loxP site, the cDNA fused to EGFP, an FRT-flanked neomycin resistance cassette, a loxP site and STOP/polyadenylation cassette. Cre-mediated recombination removed the fusion cDNA and selection cassette. (J:210870)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp1a3 Mutation:  43 strains or lines available
Original:  J:210870 Ikeda K, et al., Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice. J Physiol. 2013 Jul 1;591(Pt 13):3433-49
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory