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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spictm2Kmm
targeted mutation 2, Kenneth Murphy
MGI:5572011
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spictm2Kmm/Spictm2Kmm 129S6/SvEvTac-Spictm2Kmm MGI:5572021
cx2
 		Hmox1tm1Poss/Hmox1tm1Poss
Spictm2Kmm/Spictm2Kmm 		involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * FVB/N MGI:5572785


Genotype
MGI:5572021
hm1
Allelic
Composition		 Spictm2Kmm/Spictm2Kmm
Genetic
Background		 129S6/SvEvTac-Spictm2Kmm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spictm2Kmm mutation (0 available); any Spic mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:210804 )
• mice are viable and fertile




Genotype
MGI:5572785
cx2
Allelic
Composition		 Hmox1tm1Poss/Hmox1tm1Poss
Spictm2Kmm/Spictm2Kmm
Genetic
Background		 involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmox1tm1Poss mutation (1 available); any Hmox1 mutation (34 available)
Spictm2Kmm mutation (0 available); any Spic mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased macrophage cell number ( J:210804 )
• exposure to high levels of heme results in decreased numbers of bone marrow derived macrophages (BMDM) within 24 hours
• mice have reduced numbers of splenic red pulp macrophages and bone marrow macrophages

immune system
decreased macrophage cell number ( J:210804 )
• exposure to high levels of heme results in decreased numbers of bone marrow derived macrophages (BMDM) within 24 hours
• mice have reduced numbers of splenic red pulp macrophages and bone marrow macrophages




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory