Phenotypes associated with this allele

• Allele Symbol: Diaph3^{tm1b(KOMP)Mbp}
• Allele Name: targeted mutation 1b, Mouse Biology Program, UC Davis
• Allele ID: MGI:5571349
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Diaph3^tm1b(KOMP)Mbp/Diaph3^tm1b(KOMP)Mbp	C57BL/6N-Diaph3^tm1b(KOMP)Mbp/J	MGI:5756991
ht2	Diaph3^tm1b(KOMP)Mbp/Diaph3^+	C57BL/6N-Diaph3^tm1b(KOMP)Mbp/J	MGI:5756990

Genotype
MGI:5756991

hm1

• Allelic Composition: Diaph3^{tm1b(KOMP)Mbp}/Diaph3^{tm1b(KOMP)Mbp}
• Genetic Background: C57BL/6N-Diaph3^{tm1b(KOMP)Mbp}/J
• Cell Lines: DEPD00534_4_E12

Data Sources

IMPC Data for Diaph3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal pericardium morphology ( J:211773 )

♂

IMPC - JAX

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - JAX

embryo

abnormal embryo turning ( J:211773 )

IMPC - JAX

embryonic growth retardation ( J:211773 )

IMPC - JAX

abnormal embryo size ( J:211773 )

IMPC - JAX

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - JAX

abnormal embryo size ( J:211773 )

IMPC - JAX

integument

pallor ( J:211773 )

IMPC - JAX

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:5756990

ht2

• Allelic Composition: Diaph3^{tm1b(KOMP)Mbp}/Diaph3⁺
• Genetic Background: C57BL/6N-Diaph3^{tm1b(KOMP)Mbp}/J
• Cell Lines: DEPD00534_4_E12

Data Sources

IMPC Data for Diaph3

behavior/neurological

impaired pupillary reflex ( J:211773 )

♂

IMPC - JAX

cardiovascular system

eye hemorrhage ( J:211773 )

IMPC - JAX

cornea vascularization ( J:211773 )

♂

IMPC - JAX

hematopoietic system

increased mean corpuscular hemoglobin concentration ( J:211773 )

IMPC - JAX

decreased mean corpuscular volume ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

decreased circulating free fatty acids level ( J:211773 )

IMPC - JAX

decreased circulating triglyceride level ( J:211773 )

♂

IMPC - JAX

pigmentation

abnormal iris pigmentation ( J:211773 )

♂

IMPC - JAX

vision/eye

impaired pupillary reflex ( J:211773 )

♂

IMPC - JAX

eye hemorrhage ( J:211773 )

IMPC - JAX

abnormal iris morphology ( J:211773 )

♂

IMPC - JAX

abnormal iris pigmentation ( J:211773 )

♂

IMPC - JAX

abnormal iris transillumination ( J:211773 )

♂

IMPC - JAX

abnormal placement of pupils ( J:211773 )

♂

IMPC - JAX

irregularly shaped pupil ( J:211773 )

♂

IMPC - JAX

mydriasis ( J:211773 )

IMPC - JAX

abnormal cornea morphology ( J:211773 )

♂

IMPC - JAX

cornea vascularization ( J:211773 )

♂

IMPC - JAX

cornea deposits ( J:211773 )

♂

IMPC - JAX

cornea opacity ( J:211773 )

♂

IMPC - JAX

sclerocornea ( J:211773 )

♂

IMPC - JAX

exophthalmos ( J:211773 )

♂

IMPC - JAX

abnormal eyelid morphology ( J:211773 )

♂

IMPC - JAX

narrow eye opening ( J:211773 )

♂

IMPC - JAX

eyelids fail to open ( J:211773 )

♂

IMPC - JAX