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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ano1tm2Jrr
targeted mutation 2, Jason Rock
MGI:5569641
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ano1tm2Jrr/Ano1tm2Jrr
Tg(NPHS2-cre)295Lbh/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5569649
cn2
 		Ano1tm2Jrr/Ano1tm2Jrr
Tg(Cdh16-cre)91Igr/0 		involves: 129S6/SvEvTac * ICR MGI:5569648
cn3
 		Ano1tm2Jrr/Ano1tm2Jrr
Tg(Vil1-cre)997Gum/0 		involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:6151440


Genotype
MGI:5569649
cn1
Allelic
Composition		 Ano1tm2Jrr/Ano1tm2Jrr
Tg(NPHS2-cre)295Lbh/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano1tm2Jrr mutation (0 available); any Ano1 mutation (60 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:210158 )
N
• mice exhibit normal glomerular filters, podocytes, numbers of reabsorption vesicles in proximal tubular epithelial cells, glomerular filtration rate and urine electrolyte excretion




Genotype
MGI:5569648
cn2
Allelic
Composition		 Ano1tm2Jrr/Ano1tm2Jrr
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129S6/SvEvTac * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano1tm2Jrr mutation (0 available); any Ano1 mutation (60 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
decreased urine potassium level ( J:210158 )
• at 8 to 12 weeks
decreased urine sodium level ( J:210158 )
• at 8 to 12 weeks
increased urine protein level ( J:210158 )
• at P1
• however, this difference faded as animals age
albuminuria ( J:210158 )
• macro-albuminuria
abnormal renal tubule epithelium morphology ( J:210158 )
• proximal tubular epithelial (PTE) cells exhibit accumulation of intracellular endosomal vesicles unlike in wild-type cells
• PTE cells are more hyperpolarized and acidic with decreased albumin uptake compared with wild-type cells

homeostasis/metabolism
decreased urine potassium level ( J:210158 )
• at 8 to 12 weeks
decreased urine sodium level ( J:210158 )
• at 8 to 12 weeks
increased urine protein level ( J:210158 )
• at P1
• however, this difference faded as animals age
albuminuria ( J:210158 )
• macro-albuminuria




Genotype
MGI:6151440
cn3
Allelic
Composition		 Ano1tm2Jrr/Ano1tm2Jrr
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano1tm2Jrr mutation (0 available); any Ano1 mutation (60 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased intestinal epithelial chloride transmembrane transport ( J:260534 )
• calcium-activated chloride ion secretion and effects of niflumic acid are almost completely abolished in the ileum and proximal and distal colon compared with wild-type mice
• however, transport in the jejunum is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory