Phenotypes associated with this allele

• Allele Symbol: Insig1^tm1.1Aztc
• Allele Name: targeted mutation 1.1, Astrazeneca Transgenic Center
• Allele ID: MGI:5568496
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Insig1^tm1.1Aztc/Insig1^tm1.1Aztc	Not Specified	MGI:5568497

Genotype
MGI:5568497

hm1

• Allelic Composition: Insig1^tm1.1Aztc/Insig1^tm1.1Aztc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased subcutaneous adipose tissue amount ( J:208931 )

abnormal white fat cell morphology ( J:208931 )

• increased number of smaller adipocytes in gonadal white adipose tissue compared with wild-type mice

abnormal white fat cell differentation ( J:208931 )

• increased lipid accumulation in white adipose preadipocytes

increased gonadal fat pad weight ( J:208931 )

growth/size/body

decreased body weight ( J:208931 )

• from 3 weeks

decreased body length ( J:208931 )

• from 3 weeks

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208931 )

N • mice exhibit normal glucose tolerance, insulin sensitivity, respiratory exchange ratio and energy expenditure

decreased circulating triglyceride level ( J:208931 )

behavior/neurological

behavior/neurological phenotype ( J:208931 )

N • mice exhibit normal food intake

cellular

abnormal white fat cell differentation ( J:208931 )

• increased lipid accumulation in white adipose preadipocytes

integument

increased subcutaneous adipose tissue amount ( J:208931 )