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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxw11tm1Ybn
targeted mutation 1, Yinon Ben-Neriah
MGI:5568086
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Btrctm1Paga/Btrctm1Paga
Fbxw11tm1Ybn/Fbxw11tm1Ybn
Tg(Vil1-cre/ERT2)23Syr/? 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 MGI:5568951
cn2
 		Btrctm1Paga/Btrc+
Fbxw11tm1Ybn/Fbxw11tm1Ybn
Tg(Vil1-cre/ERT2)23Syr/? 		involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 MGI:5568952


Genotype
MGI:5568951
cn1
Allelic
Composition		 Btrctm1Paga/Btrctm1Paga
Fbxw11tm1Ybn/Fbxw11tm1Ybn
Tg(Vil1-cre/ERT2)23Syr/?
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btrctm1Paga mutation (2 available); any Btrc mutation (47 available)
Fbxw11tm1Ybn mutation (0 available); any Fbxw11 mutation (71 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
rectal hemorrhage ( J:206654 )
• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours
abnormal enterocyte morphology ( J:206654 )
• wide gaps in epithelial tight junctions found in enterocytes following tamoxifen administration
abnormal intestinal mucosa morphology ( J:206654 )
• loss of most epithelial cells in large intestine following tamoxifen administration
• remaining mucosa is infiltrated with inflammatory and immune cells
• intestinal barrier disruption observed as early as 24 hours after tamoxifen treatment
abnormal large intestine crypts of Lieberkuhn morphology ( J:206654 )
• unrecognizable crypt structures in large intestine by day 5 following tamoxifen administration
abnormal colon morphology ( J:206654 )
• mice develop severe colitis following tamoxifen administration
• loss of most epithelial cells in large intestine following tamoxifen administration
• remaining mucosa is infiltrated with inflammatory and immune cells
diarrhea ( J:206654 )
• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours
intestinal inflammation ( J:206654 )
• inflammation in small and large intestines following tamoxifen administration

cellular
abnormal centrosome morphology ( J:206654 )
• more than 2 centrosomes observed in enterocytes following tamoxifen administration
abnormal mitosis ( J:206654 )
• mitosis is abnormally prolonged in enterocytes following tamoxifen administration
abnormal mitotic spindle morphology ( J:206654 )
• mitotic enterocytes have abnormal spindles following tamoxifen administration
chromosomal instability ( J:206654 )
• observed in enterocytes following tamoxifen administration

cardiovascular system
rectal hemorrhage ( J:206654 )
• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours

endocrine/exocrine glands
abnormal large intestine crypts of Lieberkuhn morphology ( J:206654 )
• unrecognizable crypt structures in large intestine by day 5 following tamoxifen administration

homeostasis/metabolism
increased circulating interleukin-1 beta level ( J:206654 )
• increase in IL1b levels beginning day 1 and spiking on day 3 following tamoxifen administration

immune system
intestinal inflammation ( J:206654 )
• inflammation in small and large intestines following tamoxifen administration
increased circulating interleukin-1 beta level ( J:206654 )
• increase in IL1b levels beginning day 1 and spiking on day 3 following tamoxifen administration

mortality/aging
premature death ( J:206654 )
• appearance of severe diarrhea and rectal bleeding in mice given tamoxifen is followed by death within 24 hours




Genotype
MGI:5568952
cn2
Allelic
Composition		 Btrctm1Paga/Btrc+
Fbxw11tm1Ybn/Fbxw11tm1Ybn
Tg(Vil1-cre/ERT2)23Syr/?
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btrctm1Paga mutation (2 available); any Btrc mutation (47 available)
Fbxw11tm1Ybn mutation (0 available); any Fbxw11 mutation (71 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal epithelium morphology ( J:206654 )
• severe inflammation and a disrupted epithelial layer occurs 4 days after tamoxifen administration
abnormal enterocyte morphology ( J:206654 )
• wide gaps in enterocyte epithelial tight junctions following tamoxifen administration
abnormal intestinal mucosa morphology ( J:206654 )
• mucositis observed in colon following tamoxifen administration
• spontaneous recovery occurs 3 weeks after tamoxifen administration




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory