Phenotypes associated with this allele

• Allele Symbol: Npr2^tm1Fgr
• Allele Name: targeted mutation 1, Fritz G Rathjen
• Allele ID: MGI:5567993
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npr2^tm1Fgr/Npr2^tm1Fgr	involves: 129P2/OlaHsd * C57BL/6J	MGI:5568090

Genotype
MGI:5568090

hm1

• Allelic Composition: Npr2^tm1Fgr/Npr2^tm1Fgr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:205571 )

• at P56 mice display significantly reduced body size due to impaired endochondral ossification, as described for other mutants like Npr2^tm1Gar and Npr2^cn homozygotes

nervous system

abnormal trigeminal nerve morphology ( J:205571 )

• at E12.5 the trigeminal funiculus is reduced in size

abnormal dorsal root ganglion morphology ( J:205571 )

• animals lack bifurcation of DRG axons at the dorsal root entry zone