Npr2^tm1Fgr
Targeted Allele Detail

Summary

• Symbol: Npr2^tm1Fgr
• Name: natriuretic peptide receptor 2; targeted mutation 1, Fritz G Rathjen
• MGI ID: MGI:5567993
• Synonyms: Npr2^lacZ
• Gene: Npr2 Location: Chr4:43631935-43651244 bp, + strand Genetic Position: Chr4, 23.05 cM
• Alliance: Npr2^tm1Fgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205571
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 of Npr2 was replaced with an nls-lacZ (nuclear localization sequence-lacZ) expression cassette and polyadenylation sequence by homologous recombination in ES cells. The targeting vector also contained a self-excising cre recombinase-neo cassette (cre is expressed from a testis-specific promoter, so the neo is deleted in the male germline). No Npr2 protein was detected in samples from homozygotes. (J:205571)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npr2 Mutation: 63 strains or lines available

References

• Original: J:205571 Ter-Avetisyan G, et al., Bifurcation of Axons from Cranial Sensory Neurons Is Disabled in the Absence of Npr2-Induced cGMP Signaling. J Neurosci. 2014 Jan 15;34(3):737-47
• All: 5 reference(s)