About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad7tm1Gkg
targeted mutation 1, George K Gittes
MGI:5567932
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Smad7tm1Gkg/Smad7tm1Gkg
Tg(Pdx1-cre/Esr1*)#Dam/0 		involves: C57BL/6 * CBA MGI:5567933


Genotype
MGI:5567933
cn1
Allelic
Composition		 Smad7tm1Gkg/Smad7tm1Gkg
Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad7tm1Gkg mutation (0 available); any Smad7 mutation (53 available)
Tg(Pdx1-cre/Esr1*)#Dam mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic beta cell differentiation ( J:198451 )
• reduced immature beta cells at E17.5 in tamoxifen-treated mice
decreased pancreatic alpha cell number ( J:198451 )
• at E17.5 in tamoxifen-treated mice
decreased pancreatic beta cell number ( J:198451 )
• at E17.5 in tamoxifen-treated mice

cellular
abnormal pancreatic beta cell differentiation ( J:198451 )
• reduced immature beta cells at E17.5 in tamoxifen-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory