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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad7tm1Gkg
targeted mutation 1, George K Gittes
MGI:5567932
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Smad7tm1Gkg/Smad7tm1Gkg
Tg(Pdx1-cre/Esr1*)#Dam/0 		involves: C57BL/6 * CBA MGI:5567933


Genotype
MGI:5567933
cn1
Allelic
Composition		 Smad7tm1Gkg/Smad7tm1Gkg
Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad7tm1Gkg mutation (0 available); any Smad7 mutation (55 available)
Tg(Pdx1-cre/Esr1*)#Dam mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic beta cell differentiation ( J:198451 )
• reduced immature beta cells at E17.5 in tamoxifen-treated mice
decreased pancreatic alpha cell number ( J:198451 )
• at E17.5 in tamoxifen-treated mice
decreased pancreatic beta cell number ( J:198451 )
• at E17.5 in tamoxifen-treated mice

cellular
abnormal pancreatic beta cell differentiation ( J:198451 )
• reduced immature beta cells at E17.5 in tamoxifen-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory