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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Gcg-rtTA)#Herr
transgene insertion, Pedro Luis Herrera
MGI:5567083
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		\Gt(ROSA)26Sortm1(EYFP)Cos/\Gt(ROSA)26Sor+
\Hprt1tm1(Ins2-HBEGF)Herr/Y
\Tg(Gcg-rtTA)#Herr/0
\Tg(tetO-cre)1Jaw/0 		involves: 129X1/SvJ * C57BL/6 MGI:5567830


Genotype
MGI:5567830
cn1
Allelic
Composition		 \Gt(ROSA)26Sortm1(EYFP)Cos/\Gt(ROSA)26Sor+
\Hprt1tm1(Ins2-HBEGF)Herr/Y
\Tg(Gcg-rtTA)#Herr/0
\Tg(tetO-cre)1Jaw/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (23 available); any Gt(ROSA)26Sor mutation (1097 available)
Hprt1tm1(Ins2-HBEGF)Herr mutation (0 available); any Hprt1 mutation (1280 available)
Tg(Gcg-rtTA)#Herr mutation (0 available)
Tg(tetO-cre)1Jaw mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic alpha cell differentiation ( J:159291 )
• alpha cells in diphtheria-treated mice transdifferentiate into beta cells

cellular
abnormal pancreatic alpha cell differentiation ( J:159291 )
• alpha cells in diphtheria-treated mice transdifferentiate into beta cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory